DUSP8 - Dual specificity protein phosphatase 8 - human protein (Function)
 
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Protein
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References

 
DUSP8 »  Dual specificity protein phosphatase 8   [ EC 3.1.3.48EC 3.1.3.16 ]
 
Protein also known as:  Dual specificity protein phosphatase hVH-5.
Gene name:  DUSP8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This protein shows both activity toward tyrosine-protein phosphate as well as with serine/threonine-protein phosphate (By similarity).  
  • CuratedUniProtKB
GO molecular function 
MAP kinase tyrosine/serine/threonine phosphatase activitydefinition[GO:0017017] silver  
  • IBARefGenome
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
  • IEAEC 2 GO
GO biological process 
Inactivation of MAPK activitydefinition[GO:0000188] silver  
  • IBARefGenome
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
1
  • TASGOC
Protein dephosphorylationdefinition[GO:0006470] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
  • CuratedUniProtKB
EC 3.1.3.16: [a protein]-serine/threonine phosphate + H(2)O [a protein]-serine/threonine + phosphate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+1850  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1850
PRO: PR:Q13202