GRIN2B - Glutamate receptor ionotropic, NMDA 2B - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
GRIN2B »  Glutamate receptor ionotropic, NMDA 2B  (GluN2B)
 
Protein also known as:  Glutamate [NMDA] receptor subunit epsilon-2.
Gene name:  GRIN2B
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 120 1
GENE REF ISO

Function

 show evidences
Overview 
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Calcium channel activitydefinition[GO:0005262] silver  
  • IEAOrtholog Compara
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234] silver  
  • IBARefGenome
Glycine bindingdefinition[GO:0016594]  
1
  • IDAUniProtKB
N-methyl-D-aspartate selective glutamate receptor activitydefinition[GO:0004972] silver  
  • IBARefGenome
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
  • ISSOrtholog Curator
GO biological process 
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
Behavioral response to paindefinition[GO:0048266] silver  
  • IEAOrtholog Compara
Detection of mechanical stimulus involved in sensory perception of paindefinition[GO:0050966] silver  
  • IEAOrtholog Compara
Glutamate receptor signaling pathwaydefinition[GO:0007215]  
1
  • TASPINC
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IBARefGenome
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235] silver  
  • IBARefGenome
Learningdefinition[GO:0007612] silver  
  • IEAOrtholog Compara
Learning or memorydefinition[GO:0007611]  
1
  • TASPINC
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Regulation of synaptic plasticitydefinition[GO:0048167] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471]  
1
  • IDAUniProtKB
Sensory organ developmentdefinition[GO:0007423] silver  
  • IEAOrtholog Compara
Startle responsedefinition[GO:0001964] silver  
  • IEAOrtholog Compara
Suckling behaviordefinition[GO:0001967] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+2904  
Amyotrophic lateral sclerosis (ALS)  hsa05014+2904  
Dopaminergic synapse  hsa04728+2904  
Glutamatergic synapse  hsa04724+2904  
Huntington's disease  hsa05016+2904  
Long-term potentiation  hsa04720+2904  
Neuroactive ligand-receptor interaction  hsa04080+2904  
Systemic lupus erythematosus  hsa05322+2904  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIN2B
GenomeRNAi: 2904
PRO: PR:Q13224
Chemistry
GuidetoPHARMACOLOGY: 457