CHIT1 - Chitotriosidase-1 - human protein (Function)
 
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Protein
Gene
References

 
CHIT1 »  Chitotriosidase-1   [ EC 3.2.1.14 ]
 
Protein also known as:  Chitinase-1.
Gene name:  CHIT1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 76 4
GENE REF ISO

Function

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Overview 
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens.  
3
  • CuratedUniProtKB
Isoform  Iso 3   Has no enzymatic activity.  
3
  • CuratedUniProtKB
GO molecular function 
Chitin bindingdefinition[GO:0008061]  
1
  • TASUniProtKB
Chitinase activitydefinition[GO:0004568]  
1
  • TASUniProtKB
Endochitinase activitydefinition[GO:0008843]  
1
  • IDAUniProtKB
GO biological process 
Chitin catabolic processdefinition[GO:0006032]  
2
  • IDAUniProtKB
Immune responsedefinition[GO:0006955]  
1
  • NASUniProtKB
Polysaccharide catabolic processdefinition[GO:0000272]  
  • IEAUniProtKB KW
Response to bacteriumdefinition[GO:0009617]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.2.1.14: Random hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.  
3
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathways:
Carbohydrate-Binding Module Family 14  CBM14  
Glycoside Hydrolase Family 18  GH18  
Pathways 
According to KEGG, this protein belongs to the following pathway:
Amino sugar and nucleotide sugar metabolism  hsa00520+1118  
Note 
Very high plasma levels of CHIT1 are found in patients with Gaucher disease type 1 (GD I). Can be used as diagnostic aid and to evaluate the success of treatment that brings levels back to normal.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Chitin degradation  definition   [KW-0146]
Polysaccharide degradation  definition   [KW-0624]
Molecular function 
Glycosidase  definition   [KW-0326]
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 1118
PRO: PR:Q13231