MAP3K1 - Mitogen-activated protein kinase kinase kinase 1 - human protein (Function)
 
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MAP3K1 »  Mitogen-activated protein kinase kinase kinase 1   [ EC 2.7.11.25 ]
 
Protein also known as:  MAPK/ERK kinase kinase 1 (MEKK 1).
Gene name:  MAP3K1
Entry whose protein(s) existence is based on evidence at protein level
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1 92 1
GENE REF ISO

Function

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Overview 
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
JUN kinase kinase activitydefinition[GO:0008545] silver  
1
  • Ortholog Compara
MAP kinase kinase kinase activitydefinition[GO:0004709]  
2
  • UniProtKB
  • RefGenome
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • MGI
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • RefGenome
Activation of JUN kinase activitydefinition[GO:0007257] silver  
1
  • Ortholog Compara
Activation of MAPKK activitydefinition[GO:0000186]  
3
  • GOC
  • EC 2 GO
  • RefGenome
Apoptotic mitochondrial changesdefinition[GO:0008637] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • RefGenome
Cellular response to mechanical stimulusdefinition[GO:0071260]  
1
  • UniProtKB
Epithelial cell morphogenesisdefinition[GO:0003382] silver  
1
  • Ortholog Compara
Eyelid development in camera-type eyedefinition[GO:0061029] silver  
1
  • Ortholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • RefGenome
Positive regulation of actin filament polymerizationdefinition[GO:0030838] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of cell migrationdefinition[GO:0030334] silver  
1
  • Ortholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by autophosphorylation on Thr-1400 and Thr-1412 following oligomerization.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
GnRH signaling pathway  hsa04912+4214  
HTLV-I infection  hsa05166+4214  
MAPK signaling pathway  hsa04010+4214  
Neurotrophin signaling pathway  hsa04722+4214  
RIG-I-like receptor signaling pathway  hsa04622+4214  
Ubiquitin mediated proteolysis  hsa04120+4214  
According to Reactome, this protein belongs to the following pathways:
FCERI mediated MAPK activation  REACT_163701  
MyD88 cascade initiated on plasma membrane  REACT_27215  
MyD88:Mal cascade initiated on plasma membrane  REACT_6788  
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation  REACT_25024  
TRAF6 mediated NF-kB activation  REACT_24969  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K1
GenomeRNAi: 4214
PRO: PR:Q13233
Chemistry
GuidetoPHARMACOLOGY: 2069