PRKG2 - cGMP-dependent protein kinase 2 - human protein (Function)
 
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PRKG2 »  cGMP-dependent protein kinase 2   [ EC 2.7.11.12 ]  (cGK2)
 
Protein also known as:  cGMP-dependent protein kinase II (cGKII).
Gene name:  PRKG2
Entry whose protein(s) existence is based on evidence at protein level
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1 33 1
GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
cGMP bindingdefinition[GO:0030553]  
  • IEAUniProtKB KW
cGMP-dependent protein kinase activitydefinition[GO:0004692]  
  • IEAEC 2 GO
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
GO biological process 
Circadian regulation of gene expressiondefinition[GO:0032922] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.12: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Binding of cGMP results in enzyme activation.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Gap junction  hsa04540+5593  
Long-term depression  hsa04730+5593  
Olfactory transduction  hsa04740+5593  
Salivary secretion  hsa04970+5593  
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 5593
PRO: PR:Q13237
Chemistry
GuidetoPHARMACOLOGY: 1493