NOG - Noggin - human protein (Function)
 
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NOG »  Noggin
 
Gene name:  NOG
Family name: Noggin
Entry whose protein(s) existence is based on evidence at protein level
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1 59 1
GENE REF ISO

Function

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Overview 
Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine bindingdefinition[GO:0019955]  
1
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IDABHF-UCL
GO biological process 
Axial mesoderm developmentdefinition[GO:0048318] silver  
  • IEAOrtholog Compara
Cartilage developmentdefinition[GO:0051216]  
  • IEAUniProtKB KW
Cell differentiation in hindbraindefinition[GO:0021533]  
1
  • IMPBHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773] silver  
  • IEAOrtholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953]  
1
  • IDABHF-UCL
Embryonic digit morphogenesisdefinition[GO:0042733]  
1
  • IMPBHF-UCL
Embryonic skeletal joint morphogenesisdefinition[GO:0060272]  
1
  • IMPBHF-UCL
Embryonic skeletal system developmentdefinition[GO:0048706]  
1
  • IMPBHF-UCL
Endoderm formationdefinition[GO:0001706] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Face morphogenesisdefinition[GO:0060325] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationdefinition[GO:0060825]  
1
  • IMPBHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Limb developmentdefinition[GO:0060173]  
1
  • IMPBHF-UCL
Lung morphogenesisdefinition[GO:0060425] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
  • IEAOrtholog Compara
Middle ear morphogenesisdefinition[GO:0042474]  
1
  • IMPBHF-UCL
Motor neuron axon guidancedefinition[GO:0008045] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234] silver  
  • IEAOrtholog Compara
Negative regulation of astrocyte differentiationdefinition[GO:0048712]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
3
  • IDABHF-UCL
  • ISSOrtholog Curator
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • IDABHF-UCL
Negative regulation of cardiac muscle cell proliferationdefinition[GO:0060044]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
  • IEAOrtholog Compara
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IDABHF-UCL
Negative regulation of cytokine activitydefinition[GO:0060302]  
1
  • IPIBHF-UCL
Negative regulation of osteoblast differentiationdefinition[GO:0045668]  
1
  • IDABHF-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0060394]  
1
  • IDABHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neural plate morphogenesisdefinition[GO:0001839] silver  
  • IEAOrtholog Compara
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Notochord morphogenesisdefinition[GO:0048570] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Pituitary gland developmentdefinition[GO:0021983] silver  
  • IEAOrtholog Compara
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
  • IEAOrtholog Compara
Positive regulation of glomerulus developmentdefinition[GO:0090193]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Prostatic bud formationdefinition[GO:0060513] silver  
  • IEAOrtholog Compara
Regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationdefinition[GO:2000313]  
1
  • IMPBHF-UCL
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Somatic stem cell maintenancedefinition[GO:0035019]  
1
  • IMPBHF-UCL
Somite developmentdefinition[GO:0061053] silver  
  • IEAOrtholog Compara
Spinal cord developmentdefinition[GO:0021510] silver  
  • IEAOrtholog Compara
Ureteric bud formationdefinition[GO:0060676] silver  
  • IEAOrtholog Compara
Wound healingdefinition[GO:0042060]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+9241  
According to Reactome, this protein belongs to the following pathway:
Signaling by BMP  REACT_12034  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Noggin_(protein)
GenomeRNAi: 9241
PRO: PR:Q13253