NOG - Noggin - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
NOG »  Noggin
 
Gene name:  NOG
Family name: Noggin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 64 1
GENE REF ISO

Function

 show evidences
Overview 
Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed21976273).  
3
  • UniProtKB
GO molecular function 
Cytokine bindingdefinition[GO:0019955]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • BHF-UCL
GO biological process 
Axial mesoderm developmentdefinition[GO:0048318] silver  
1
  • Ortholog Compara
Cartilage developmentdefinition[GO:0051216]  
1
  • UniProtKB KW
Cell differentiation in hindbraindefinition[GO:0021533]  
1
  • BHF-UCL
Cellular response to BMP stimulusdefinition[GO:0071773] silver  
1
  • Ortholog Compara
Dorsal/ventral pattern formationdefinition[GO:0009953]  
1
  • BHF-UCL
Embryonic digit morphogenesisdefinition[GO:0042733]  
1
  • BHF-UCL
Embryonic skeletal joint morphogenesisdefinition[GO:0060272]  
1
  • BHF-UCL
Embryonic skeletal system developmentdefinition[GO:0048706]  
1
  • BHF-UCL
Endoderm formationdefinition[GO:0001706] silver  
1
  • Ortholog Compara
Epithelial to mesenchymal transitiondefinition[GO:0001837]  
2
  • BHF-UCL
  • Ortholog Curator
Face morphogenesisdefinition[GO:0060325] silver  
1
  • Ortholog Compara
Fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationdefinition[GO:0060825]  
1
  • BHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Limb developmentdefinition[GO:0060173]  
1
  • BHF-UCL
Lung morphogenesisdefinition[GO:0060425] silver  
1
  • Ortholog Compara
Mesoderm formationdefinition[GO:0001707] silver  
1
  • Ortholog Compara
Middle ear morphogenesisdefinition[GO:0042474]  
1
  • BHF-UCL
Motor neuron axon guidancedefinition[GO:0008045] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic signaling pathwaydefinition[GO:2001234] silver  
1
  • Ortholog Compara
Negative regulation of astrocyte differentiationdefinition[GO:0048712]  
2
  • BHF-UCL
  • Ortholog Curator
Negative regulation of BMP signaling pathwaydefinition[GO:0030514]  
4
  • BHF-UCL
  • Ortholog Curator
Negative regulation of canonical Wnt signaling pathwaydefinition[GO:0090090]  
1
  • BHF-UCL
Negative regulation of cardiac muscle cell proliferationdefinition[GO:0060044]  
2
  • BHF-UCL
  • Ortholog Curator
Negative regulation of cartilage developmentdefinition[GO:0061037] silver  
1
  • Ortholog Compara
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • BHF-UCL
Negative regulation of cytokine activitydefinition[GO:0060302]  
1
  • BHF-UCL
Negative regulation of osteoblast differentiationdefinition[GO:0045668]  
1
  • BHF-UCL
Negative regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0060394]  
1
  • BHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Neural plate morphogenesisdefinition[GO:0001839] silver  
1
  • Ortholog Compara
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Notochord morphogenesisdefinition[GO:0048570] silver  
1
  • Ortholog Compara
Osteoblast differentiationdefinition[GO:0001649]  
2
  • BHF-UCL
  • Ortholog Curator
Pituitary gland developmentdefinition[GO:0021983] silver  
1
  • Ortholog Compara
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
1
  • Ortholog Curator
Positive regulation of epithelial cell proliferationdefinition[GO:0050679] silver  
1
  • Ortholog Compara
Positive regulation of glomerulus developmentdefinition[GO:0090193]  
1
  • Ortholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
1
  • Ortholog Compara
Prostatic bud formationdefinition[GO:0060513] silver  
1
  • Ortholog Compara
Regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formationdefinition[GO:2000313]  
1
  • BHF-UCL
Skeletal system developmentdefinition[GO:0001501]  
1
  • PINC
Somatic stem cell maintenancedefinition[GO:0035019]  
1
  • BHF-UCL
Somite developmentdefinition[GO:0061053] silver  
1
  • Ortholog Compara
Spinal cord developmentdefinition[GO:0021510] silver  
1
  • Ortholog Compara
Ureteric bud formationdefinition[GO:0060676] silver  
1
  • Ortholog Compara
Wound healingdefinition[GO:0042060]  
2
  • BHF-UCL
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
TGF-beta signaling pathway  hsa04350+9241  
According to Reactome, this protein belongs to the following pathway:
Signaling by BMP  REACT_12034  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Noggin_(protein)
GenomeRNAi: 9241
PRO: PR:Q13253