GRM1 - Metabotropic glutamate receptor 1 - human protein (Function)
 
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GRM1 »  Metabotropic glutamate receptor 1  (mGluR1)
 
Gene name:  GRM1
Entry whose protein(s) existence is based on evidence at protein level
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1 45 3
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.  
3
  • UniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.7.1  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB
Glutamate receptor activitydefinition[GO:0008066]  
3
  • UniProtKB
  • FlyBase
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
1
  • Ortholog Compara
Activation of MAPKK activitydefinition[GO:0000186] silver  
1
  • Ortholog Compara
Cellular response to electrical stimulusdefinition[GO:0071257] silver  
1
  • Ortholog Compara
Dimeric G-protein coupled receptor signaling pathwaydefinition[GO:0038042]  
1
  • UniProtKB
G-protein coupled glutamate receptor signaling pathwaydefinition[GO:0007216]  
2
  • UniProtKB
  • RefGenome
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • UniProtKB
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205]  
1
  • RefGenome
Regulation of sensory perception of paindefinition[GO:0051930] silver  
1
  • Ortholog Compara
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966]  
1
  • RefGenome
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Enzymatic activity 
It is regulated in the following manner
Signaling is inhibited by the antagonist LY341495. The LY341495 binding site partially overlaps with the glutamate binding site. Signaling is also inhibited by synthetic allosteric regulators, such as FITM (4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide) that bind in a pocket between the transmembrane helices.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+2911  
Gap junction  hsa04540+2911  
Glutamatergic synapse  hsa04724+2911  
Huntington's disease  hsa05016+2911  
Long-term depression  hsa04730+2911  
Long-term potentiation  hsa04720+2911  
Neuroactive ligand-receptor interaction  hsa04080+2911  
According to Reactome, this protein belongs to the following pathways:
Class C/3 (Metabotropic glutamate/pheromone receptors)  REACT_18319  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Metabotropic_glutamate_receptor_1
GenomeRNAi: 2911
PRO: PR:Q13255
Chemistry
GuidetoPHARMACOLOGY: 289