GRM1 - Metabotropic glutamate receptor 1 - human protein (Function)
 
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GRM1 »  Metabotropic glutamate receptor 1  (mGluR1)
 
Gene name:  GRM1
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

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Overview 
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.7.1  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASUniProtKB
Glutamate receptor activitydefinition[GO:0008066]  
3
  • IDAUniProtKB
  • IDAFlyBase
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Activation of MAPK activitydefinition[GO:0000187] silver  
  • IEAOrtholog Compara
Activation of MAPKK activitydefinition[GO:0000186] silver  
  • IEAOrtholog Compara
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Cellular response to electrical stimulusdefinition[GO:0071257] silver  
  • IEAOrtholog Compara
Dimeric G-protein coupled receptor signaling pathwaydefinition[GO:0038042]  
1
  • IDAUniProtKB
G-protein coupled glutamate receptor signaling pathwaydefinition[GO:0007216]  
1
  • IMPUniProtKB
  • IBARefGenome
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • IDAUniProtKB
Locomotory behaviordefinition[GO:0007626] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • IMPUniProtKB
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
  • IBARefGenome
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966] silver  
  • IBARefGenome
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+2911  
Gap junction  hsa04540+2911  
Glutamatergic synapse  hsa04724+2911  
Huntington's disease  hsa05016+2911  
Long-term depression  hsa04730+2911  
Long-term potentiation  hsa04720+2911  
Neuroactive ligand-receptor interaction  hsa04080+2911  
According to Reactome, this protein belongs to the following pathways:
Class C/3 (Metabotropic glutamate/pheromone receptors)  REACT_18319  
G alpha (q) signalling events  REACT_18283  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Metabotropic_glutamate_receptor_1
GenomeRNAi: 2911
PRO: PR:Q13255
Chemistry
GuidetoPHARMACOLOGY: 289