NR5A1 - Steroidogenic factor 1 - human protein (Function)
 
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NR5A1 »  Steroidogenic factor 1  (SF-1)
 
Protein also known as:  Nuclear receptor subfamily 5 group A member 1.
Gene name:  NR5A1
Family name: Nuclear hormone receptor » NR5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 162 1
GENE REF ISO

Function

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Overview 
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (By similarity). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.  
2
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
Enzyme bindingdefinition[GO:0019899]  
1
  • UniProtKB
Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0004879]  
1
  • PINC
Phospholipid bindingdefinition[GO:0005543]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
5
  • UniProtKB
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activitydefinition[GO:0003705]  
1
  • UniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565] silver  
1
  • InterPro 2 GO
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Transcription coactivator activitydefinition[GO:0003713]  
1
  • PINC
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Adrenal gland developmentdefinition[GO:0030325] silver  
1
  • Ortholog Compara
Cell differentiationdefinition[GO:0030154] silver  
1
  • Ortholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Hormone metabolic processdefinition[GO:0042445] silver  
1
  • Ortholog Compara
Intracellular receptor signaling pathwaydefinition[GO:0030522]  
1
  • GOC
Luteinizationdefinition[GO:0001553] silver  
1
  • Ortholog Compara
Maintenance of protein location in nucleusdefinition[GO:0051457] silver  
1
  • Ortholog Compara
Male gonad developmentdefinition[GO:0008584] silver  
1
  • Ortholog Compara
Multicellular organismal agingdefinition[GO:0010259] silver  
1
  • Ortholog Compara
Negative regulation of female gonad developmentdefinition[GO:2000195] silver  
1
  • Ortholog Compara
Positive regulation of male gonad developmentdefinition[GO:2000020]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Primary sex determinationdefinition[GO:0007538]  
1
  • PINC
Regulation of steroid biosynthetic processdefinition[GO:0050810]  
1
  • UniProtKB
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Tissue developmentdefinition[GO:0009888] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Nuclear Receptor transcription pathway  REACT_15525  
Transcriptional regulation of pluripotent stem cells  REACT_200812  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Steroidogenic_factor_1
GenomeRNAi: 2516
PRO: PR:Q13285