CRHR2 - Corticotropin-releasing factor receptor 2 - human protein (Function)
 
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CRHR2 »  Corticotropin-releasing factor receptor 2  (CRF-R2)
 
Protein also known as:  Corticotropin-releasing hormone receptor 2 (CRH-R2).
Gene name:  CRHR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.  
  • CuratedUniProtKB
GO molecular function 
Corticotrophin-releasing factor receptor activitydefinition[GO:0015056] silver  
  • IEAOrtholog Compara
Hormone activitydefinition[GO:0005179] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASPINC
Cellular response to corticotropin-releasing hormone stimulusdefinition[GO:0071376] silver  
  • IEAOrtholog Compara
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
  • IEAOrtholog Compara
Negative regulation of cAMP-mediated signalingdefinition[GO:0043951] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1395  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  REACT_18372  
G alpha (s) signalling events  REACT_19327  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Corticotropin_releasing_hormone_receptor_2
GenomeRNAi: 1395
PRO: PR:Q13324
Chemistry
GuidetoPHARMACOLOGY: 213