CRHR2 - Corticotropin-releasing factor receptor 2 - human protein (Function)
 
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CRHR2 »  Corticotropin-releasing factor receptor 2  (CRFR-2)
 
Protein also known as:  Corticotropin-releasing hormone receptor 2 (CRH-R2).
Gene name:  CRHR2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.  
1
  • UniProtKB
GO molecular function 
Corticotrophin-releasing factor receptor activitydefinition[GO:0015056] silver  
1
  • Ortholog Compara
Corticotropin-releasing hormone receptor activitydefinition[GO:0043404] silver  
1
  • Ortholog Compara
Hormone activitydefinition[GO:0005179] silver  
1
  • Ortholog Compara
Peptide hormone bindingdefinition[GO:0017046] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
GO biological process 
Actin filament organizationdefinition[GO:0007015] silver  
1
  • Ortholog Compara
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • PINC
Catecholamine biosynthetic processdefinition[GO:0042423] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166] silver  
1
  • InterPro 2 GO
Cellular response to corticotropin-releasing hormone stimulusdefinition[GO:0071376] silver  
1
  • Ortholog Compara
Cellular response to glucocorticoid stimulusdefinition[GO:0071385] silver  
1
  • Ortholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
1
  • Ortholog Compara
Epithelial cell differentiationdefinition[GO:0030855] silver  
1
  • Ortholog Compara
Gastric motilitydefinition[GO:0035482] silver  
1
  • Ortholog Compara
Hormone-mediated signaling pathwaydefinition[GO:0009755] silver  
1
  • Ortholog Compara
Hypothalamus developmentdefinition[GO:0021854] silver  
1
  • Ortholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
1
  • Ortholog Compara
Negative regulation of angiogenesisdefinition[GO:0016525] silver  
1
  • Ortholog Compara
Negative regulation of calcium ion importdefinition[GO:0090281] silver  
1
  • Ortholog Compara
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818] silver  
1
  • Ortholog Compara
Negative regulation of cAMP-mediated signalingdefinition[GO:0043951] silver  
1
  • Ortholog Compara
Negative regulation of defecationdefinition[GO:2000293] silver  
1
  • Ortholog Compara
Negative regulation of epinephrine secretiondefinition[GO:0032811] silver  
1
  • Ortholog Compara
Negative regulation of feeding behaviordefinition[GO:2000252] silver  
1
  • Ortholog Compara
Negative regulation of follicle-stimulating hormone secretiondefinition[GO:0046882] silver  
1
  • Ortholog Compara
Negative regulation of gene expressiondefinition[GO:0010629] silver  
1
  • Ortholog Compara
Negative regulation of insulin secretion involved in cellular response to glucose stimulusdefinition[GO:0061179] silver  
1
  • Ortholog Compara
Negative regulation of luteinizing hormone secretiondefinition[GO:0033685] silver  
1
  • Ortholog Compara
Negative regulation of norepinephrine secretiondefinition[GO:0010700] silver  
1
  • Ortholog Compara
Positive regulation of blood pressuredefinition[GO:0045777] silver  
1
  • Ortholog Compara
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819] silver  
1
  • Ortholog Compara
Positive regulation of cAMP-mediated signalingdefinition[GO:0043950] silver  
1
  • Ortholog Compara
Positive regulation of heart ratedefinition[GO:0010460] silver  
1
  • Ortholog Compara
Positive regulation of interleukin-6 productiondefinition[GO:0032755] silver  
1
  • Ortholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092] silver  
1
  • Ortholog Compara
Positive regulation of serotonin secretiondefinition[GO:0014064] silver  
1
  • Ortholog Compara
Positive regulation of stress-activated MAPK cascadedefinition[GO:0032874] silver  
1
  • Ortholog Compara
Protein kinase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007205] silver  
1
  • Ortholog Compara
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372] silver  
1
  • Ortholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
1
  • Ortholog Compara
Skeletal muscle tissue growthdefinition[GO:0048630] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1395  
According to Reactome, this protein belongs to the following pathways:
Class B/2 (Secretin family receptors)  R-HSA-373080  
G alpha (s) signalling events  R-HSA-418555  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Corticotropin_releasing_hormone_receptor_2
GenomeRNAi: 1395
PRO: PR:Q13324
Chemistry
GuidetoPHARMACOLOGY: 213