SLC14A1 - Urea transporter 1 - human protein (Function)
 
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Protein
Gene
References

 
SLC14A1 »  Urea transporter 1
 
Protein also known as:  Solute carrier family 14 member 1.
Gene name:  SLC14A1
Family name: Urea transporter
Entry whose protein(s) existence is based on evidence at protein level
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1 42 2
GENE REF ISO

Function

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Overview 
Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the urea transporter (ut) family  1.A.28.1.5  
GO molecular function 
Urea channel activitydefinition[GO:0015265]  
1
  • IDAUniProtKB
Urea transmembrane transporter activitydefinition[GO:0015204]  
1
  • TASPINC
Water transmembrane transporter activitydefinition[GO:0005372] silver  
  • IEAOrtholog Compara
GO biological process 
Urea transmembrane transportdefinition[GO:0071918]  
1
  • IDAUniProtKB
Urea transportdefinition[GO:0015840]  
1
  • TASPINC
Water transportdefinition[GO:0006833] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds  REACT_19305  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Blood group antigen  definition   [KW-0095]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SLC14A1
GenomeRNAi: 6563
PRO: PR:Q13336