ILK - Integrin-linked protein kinase - human protein (Function)
 
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ILK »  Integrin-linked protein kinase   [ EC 2.7.11.1 ]
 
Protein also known as:  59 kDa serine/threonine-protein kinase.
Gene name:  ILK
Entry whose protein(s) existence is based on evidence at protein level
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1 192 1
GENE REF ISO

Function

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Overview 
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Integrin bindingdefinition[GO:0005178] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
12
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
2
  • IDAUniProtKB
  • IDAMGI
SH3 domain bindingdefinition[GO:0017124] silver  
  • IEAOrtholog Compara
Signal transducer activitydefinition[GO:0004871] silver  
  • IEAOrtholog Compara
GO biological process 
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Cell agingdefinition[GO:0007569] silver  
  • IEAOrtholog Compara
Cell cycle arrestdefinition[GO:0007050] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • NASUniProtKB
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • TASPINC
Establishment or maintenance of epithelial cell apical/basal polaritydefinition[GO:0045197] silver  
  • IEAOrtholog Compara
Extracellular fibril organizationdefinition[GO:0043206] silver  
  • IEAOrtholog Compara
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • IDAMGI
Myelin assemblydefinition[GO:0032288] silver  
  • IEAOrtholog Compara
Myelination in peripheral nervous systemdefinition[GO:0022011] silver  
  • IEAOrtholog Compara
Negative regulation of cardiac muscle cell apoptotic processdefinition[GO:0010667] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of protein kinase activitydefinition[GO:0006469] silver  
  • IEAOrtholog Compara
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912] silver  
  • IEAOrtholog Compara
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662] silver  
  • IEAOrtholog Compara
Nerve developmentdefinition[GO:0021675] silver  
  • IEAOrtholog Compara
Neuron projection morphogenesisdefinition[GO:0048812] silver  
  • IEAOrtholog Compara
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Positive regulation of axon extensiondefinition[GO:0045773] silver  
  • IEAOrtholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513] silver  
  • IEAOrtholog Compara
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • IMPUniProtKB
Positive regulation of cell migrationdefinition[GO:0030335] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284] silver  
  • IEAOrtholog Compara
Positive regulation of cell-matrix adhesiondefinition[GO:0001954] silver  
  • IEAOrtholog Compara
Positive regulation of dendrite morphogenesisdefinition[GO:0050775] silver  
  • IEAOrtholog Compara
Positive regulation of MAP kinase activitydefinition[GO:0043406] silver  
  • IEAOrtholog Compara
Positive regulation of myoblast differentiationdefinition[GO:0045663] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669] silver  
  • IEAOrtholog Compara
Positive regulation of phosphorylationdefinition[GO:0042327]  
1
  • IMPUniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IMPUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein kinase B signalingdefinition[GO:0043491] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of actin cytoskeleton organizationdefinition[GO:0032956] silver  
  • IEAOrtholog Compara
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Stimulated rapidly but transiently by both cell fibronectin interactions, as well as by insulin, in a PI3-K-dependent manner, likely via the binding of PtdIns(3,4,5)P3 with a PH-like domain of ILK.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bacterial invasion of epithelial cells  hsa05100+3611  
Endometrial cancer  hsa05213+3611  
Focal adhesion  hsa04510+3611  
PPAR signaling pathway  hsa03320+3611  
According to Reactome, this protein belongs to the following pathway:
Cell-Cell communication  REACT_111155  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Integrin-linked_kinase
GenomeRNAi: 3611
PRO: PR:Q13418