NNT - NAD(P) transhydrogenase, mitochondrial - human protein (Function)
 
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Protein
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References

 
NNT »  NAD(P) transhydrogenase, mitochondrial   [ EC 1.6.1.2 ]
 
Protein also known as:  Nicotinamide nucleotide transhydrogenase.
Gene name:  NNT
Family names: In the N-terminal section AlaDH/PNT
In the C-terminal section PNT beta subunit
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.  
1
  • CuratedUniProtKB
GO molecular function 
NAD bindingdefinition[GO:0051287]  
1
  • TASUniProtKB
NAD(P)+ transhydrogenase (AB-specific) activitydefinition[GO:0008750]  
  • IEAEC 2 GO
NAD(P)+ transhydrogenase (B-specific) activitydefinition[GO:0003957]  
1
  • TASUniProtKB
NADP bindingdefinition[GO:0050661]  
1
  • IDAUniProtKB
GO biological process 
Hydrogen ion transmembrane transportdefinition[GO:1902600]  
1
  • TASGOC
Ion transmembrane transportdefinition[GO:0034220]  
1
  • TASGOC
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Proton transportdefinition[GO:0015992]  
1
  • TASUniProtKB
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • IMPUniProtKB
Transmembrane transportdefinition[GO:0055085]  
1
  • TASGOC
Tricarboxylic acid cycledefinition[GO:0006099]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.6.1.2: NADPH + NAD(+) NADP(+) + NADH.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+23530  
Nicotinate and nicotinamide metabolism  hsa00760+23530  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NNT_(gene)
GenomeRNAi: 23530
PRO: PR:Q13423