ADAM9 - Disintegrin and metalloproteinase domain-containing protein 9 - human protein (Function)
 
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ADAM9 »  Disintegrin and metalloproteinase domain-containing protein 9   [ EC 3.4.24.- ]  (ADAM 9)
 
Protein also known as:  Metalloprotease/disintegrin/cysteine-rich protein 9.
Gene name:  ADAM9
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 2
GENE REF ISO

Function

 show evidences
Overview 
Probable zinc protease. May mediate cell-cell or cell-matrix interactions.  
1
  • CuratedUniProtKB
Isoform  Iso 2   Displays alpha-secretase activity for APP.  
1
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • IMPBHF-UCL
Integrin bindingdefinition[GO:0005178]  
3
  • IPIBHF-UCL
Laminin bindingdefinition[GO:0043236]  
1
  • IMPBHF-UCL
Metalloendopeptidase activitydefinition[GO:0004222]  
2
  • IMPBHF-UCL
Metallopeptidase activitydefinition[GO:0008237]  
1
  • IMPBHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIBHF-UCL
  • IPIIntAct
Protein kinase C bindingdefinition[GO:0005080]  
1
  • ISSBHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
2
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of MAPKK activitydefinition[GO:0000186]  
1
  • IDABHF-UCL
Cell adhesiondefinition[GO:0007155]  
2
  • IMPBHF-UCL
Cell adhesion mediated by integrindefinition[GO:0033627]  
1
  • IMPBHF-UCL
Cell-cell adhesion mediated by integrindefinition[GO:0033631]  
1
  • IEPBHF-UCL
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • IMPBHF-UCL
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • IMPBHF-UCL
Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • ICBHF-UCL
Keratinocyte differentiationdefinition[GO:0030216]  
1
  • IEPBHF-UCL
Membrane protein ectodomain proteolysisdefinition[GO:0006509]  
2
  • IMPBHF-UCL
Monocyte activationdefinition[GO:0042117]  
1
  • IMPBHF-UCL
PMA-inducible membrane protein ectodomain proteolysisdefinition[GO:0051088]  
2
  • IDABHF-UCL
Positive regulation of cell adhesion mediated by integrindefinition[GO:0033630]  
1
  • IMPBHF-UCL
Positive regulation of keratinocyte migrationdefinition[GO:0051549]  
1
  • IMPBHF-UCL
Positive regulation of macrophage fusiondefinition[GO:0034241]  
1
  • IMPBHF-UCL
Positive regulation of membrane protein ectodomain proteolysisdefinition[GO:0051044]  
1
  • ISSBHF-UCL
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • IDABHF-UCL
Response to calcium iondefinition[GO:0051592]  
1
  • IMPBHF-UCL
Response to glucocorticoiddefinition[GO:0051384]  
1
  • ISSBHF-UCL
Response to hydrogen peroxidedefinition[GO:0042542]  
1
  • IMPBHF-UCL
Response to laminar fluid shear stressdefinition[GO:0034616] silver  
  • IEAOrtholog Compara
Response to manganese iondefinition[GO:0010042]  
1
  • IMPBHF-UCL
Response to tumor necrosis factordefinition[GO:0034612]  
1
  • IDABHF-UCL
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
2
  • IMPBHF-UCL
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (Probable).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Collagen degradation  REACT_150401  
Caution 
Has sometimes been referred to as ADAM-12.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM9
GenomeRNAi: 8754
PRO: PR:Q13443