ADAM15 - Disintegrin and metalloproteinase domain-containing protein 15 - human protein (Function)
 
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ADAM15 »  Disintegrin and metalloproteinase domain-containing protein 15
 
Gene name:  ADAM15
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.  
7
  • CuratedUniProtKB
GO molecular function 
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Metallopeptidase activitydefinition[GO:0008237]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIBHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
1
  • IPIBHF-UCL
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Cardiac epithelial to mesenchymal transitiondefinition[GO:0060317] silver  
  • IEAOrtholog Compara
Cell-matrix adhesiondefinition[GO:0007160]  
1
  • TASPINC
Collagen catabolic processdefinition[GO:0030574]  
  • IEAUniProtKB KW
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Tissue regenerationdefinition[GO:0042246] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by hydroxamate-type metalloproteinase inhibitors such as marimastat. Inhibited by metalloproteinase inhibitor 2 (TIMP-2) and TIMP-3 at nanomolar concentrations. Not significantly inhibited by TIMP-1 at concentrations of up to 100 nM. Not activated by PMA or ionomycin.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Degradation of the extracellular matrix  REACT_118572  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ADAM15
GenomeRNAi: 8751
PRO: PR:Q13444