FKBP5 - Peptidyl-prolyl cis-trans isomerase FKBP5 - human protein (Function)
 
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FKBP5 »  Peptidyl-prolyl cis-trans isomerase FKBP5   [ EC 5.2.1.8 ]  (PPIase FKBP5)
 
Protein also known as:  54 kDa progesterone receptor-associated immunophilin. Cleaved into:  Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed.
Gene name:  FKBP5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded.  
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  • UniProtKB
GO molecular function 
FK506 bindingdefinition[GO:0005528]  
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  • RefGenome
Heat shock protein bindingdefinition[GO:0031072]  
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  • UniProtKB
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
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  • UniProtKB
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
GO biological process 
Chaperone-mediated protein foldingdefinition[GO:0061077]  
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  • UniProtKB
Protein foldingdefinition[GO:0006457]  
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  • PINC
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
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  • GOC
  • EC 2 GO
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
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  • UniProtKB
It is regulated in the following manner
Inhibited by FK506 but not cyclosporin.  
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  • UniProtKB
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FKBP5
GenomeRNAi: 2289
PRO: PR:Q13451