FOXE3 - Forkhead box protein E3 - human protein (Function)
 
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Protein
Gene
References

 
FOXE3 »  Forkhead box protein E3
 
Protein also known as:  Forkhead-related transcription factor 8 (FREAC-8).
Gene name:  FOXE3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed22527307, PubMed25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Is required for morphogenesis and differentiation of the anterior segment of the eye (By similarity).  
4
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA bindingdefinition[GO:0000981]  
1
  • RefGenome
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • UniProtKB
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
3
  • UniProtKB
  • MGI
GO biological process 
Anatomical structure morphogenesisdefinition[GO:0009653]  
1
  • RefGenome
Cell developmentdefinition[GO:0048468] silver  
1
  • Ortholog Compara
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Ciliary body morphogenesisdefinition[GO:0061073]  
1
  • UniProtKB
Cornea development in camera-type eyedefinition[GO:0061303]  
1
  • UniProtKB
Iris morphogenesisdefinition[GO:0061072]  
1
  • UniProtKB
Lens development in camera-type eyedefinition[GO:0002088]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cell cycle arrestdefinition[GO:0071157]  
1
  • UniProtKB
Negative regulation of lens fiber cell differentiationdefinition[GO:1902747]  
1
  • UniProtKB
Positive regulation of lens epithelial cell proliferationdefinition[GO:2001111]  
2
  • UniProtKB
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • RefGenome
Trabecular meshwork developmentdefinition[GO:0002930]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • MGI
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FOXE3
GenomeRNAi: 2301
PRO: PR:Q13461