ROCK1 - Rho-associated protein kinase 1 - human protein (Function)
 
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Gene
References

 
ROCK1 »  Rho-associated protein kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Rho-associated, coiled-coil-containing protein kinase I (ROCK-I).
Gene name:  ROCK1
Entry whose protein(s) existence is based on evidence at protein level
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1 250 1
GENE REF ISO

Function

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Overview 
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.  
15
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
GTP-Rho bindingdefinition[GO:0017049] silver  
1
  • InterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • IntAct
  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
2
  • PINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
5
  • UniProtKB
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
1
  • Ortholog Compara
Apical constrictiondefinition[GO:0003383] silver  
1
  • Ortholog Compara
Bleb assemblydefinition[GO:0032060] silver  
1
  • Ortholog Compara
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • BHF-UCL
Leukocyte migrationdefinition[GO:0050900]  
1
  • BHF-UCL
Leukocyte tethering or rollingdefinition[GO:0050901]  
1
  • BHF-UCL
Membrane to membrane dockingdefinition[GO:0022614]  
1
  • BHF-UCL
Myoblast migrationdefinition[GO:0051451]  
1
  • Ortholog Curator
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • UniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of protein bindingdefinition[GO:0032091]  
1
  • UniProtKB
Positive regulation of focal adhesion assemblydefinition[GO:0051894]  
1
  • Ortholog Curator
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • UniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • UniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • UniProtKB
Regulation of establishment of cell polaritydefinition[GO:2000114]  
1
  • UniProtKB
Regulation of focal adhesion assemblydefinition[GO:0051893]  
1
  • UniProtKB
Regulation of keratinocyte differentiationdefinition[GO:0045616]  
1
  • UniProtKB
Regulation of stress fiber assemblydefinition[GO:0051492]  
1
  • UniProtKB
Rho protein signal transductiondefinition[GO:0007266] silver  
1
  • InterPro 2 GO
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Smooth muscle contractiondefinition[GO:0006939]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by RHOA binding. Inhibited by Y-27632.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+6093  
Chemokine signaling pathway  hsa04062+6093  
Focal adhesion  hsa04510+6093  
Leukocyte transendothelial migration  hsa04670+6093  
Pathogenic Escherichia coli infection  hsa05130+6093  
Regulation of actin cytoskeleton  hsa04810+6093  
Salmonella infection  hsa05132+6093  
Shigellosis  hsa05131+6093  
TGF-beta signaling pathway  hsa04350+6093  
Vascular smooth muscle contraction  hsa04270+6093  
Wnt signaling pathway  hsa04310+6093  
According to Reactome, this protein belongs to the following pathways:
Apoptotic cleavage of cellular proteins  REACT_107  
EPHA-mediated growth cone collapse  REACT_264548  
EPHB-mediated forward signaling  REACT_263952  
G alpha (12/13) signalling events  REACT_18407  
Sema4D induced cell migration and growth-cone collapse  REACT_19277  
VEGFA-VEGFR2 Pathway  REACT_264464  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ROCK1
GenomeRNAi: 6093
PRO: PR:Q13464
Chemistry
GuidetoPHARMACOLOGY: 1503