ROCK1 - Rho-associated protein kinase 1 - human protein (Function)
 
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ROCK1 »  Rho-associated protein kinase 1   [ EC 2.7.11.1 ]
 
Protein also known as:  Rho-associated, coiled-coil-containing protein kinase 1.
Gene name:  ROCK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 225 1
GENE REF ISO

Function

 show evidences
Overview 
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.  
14
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
2
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
5
  • IDAUniProtKB
Rho GTPase bindingdefinition[GO:0017048] silver  
  • IEAInterPro 2 GO
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036] silver  
  • IEAOrtholog Compara
Apical constrictiondefinition[GO:0003383] silver  
  • IEAOrtholog Compara
Bleb assemblydefinition[GO:0032060] silver  
  • IEAOrtholog Compara
Leukocyte cell-cell adhesiondefinition[GO:0007159]  
1
  • IDABHF-UCL
Leukocyte migrationdefinition[GO:0050900]  
1
  • IDABHF-UCL
Leukocyte tethering or rollingdefinition[GO:0050901]  
1
  • IDABHF-UCL
Membrane to membrane dockingdefinition[GO:0022614]  
1
  • IDABHF-UCL
Myoblast migrationdefinition[GO:0051451]  
  • ISSOrtholog Curator
Negative regulation of angiogenesisdefinition[GO:0016525]  
1
  • IMPUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Positive regulation of focal adhesion assemblydefinition[GO:0051894]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of actin cytoskeleton organizationdefinition[GO:0032956]  
1
  • TASUniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • TASUniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • TASUniProtKB
Regulation of establishment of cell polaritydefinition[GO:2000114]  
1
  • TASUniProtKB
Regulation of focal adhesion assemblydefinition[GO:0051893]  
1
  • TASUniProtKB
Regulation of keratinocyte differentiationdefinition[GO:0045616]  
1
  • IMPUniProtKB
Regulation of stress fiber assemblydefinition[GO:0051492]  
1
  • TASUniProtKB
Rho protein signal transductiondefinition[GO:0007266]  
1
  • TASPINC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Smooth muscle contractiondefinition[GO:0006939]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by RHOA binding. Inhibited by Y-27632.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+6093  
Chemokine signaling pathway  hsa04062+6093  
Focal adhesion  hsa04510+6093  
Leukocyte transendothelial migration  hsa04670+6093  
Pathogenic Escherichia coli infection  hsa05130+6093  
Regulation of actin cytoskeleton  hsa04810+6093  
Salmonella infection  hsa05132+6093  
Shigellosis  hsa05131+6093  
TGF-beta signaling pathway  hsa04350+6093  
Vascular smooth muscle contraction  hsa04270+6093  
Wnt signaling pathway  hsa04310+6093  
According to Reactome, this protein belongs to the following pathways:
Apoptotic cleavage of cellular proteins  REACT_107  
G alpha (12/13) signalling events  REACT_18407  
Sema4D induced cell migration and growth-cone collapse  REACT_19277  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ROCK1
GenomeRNAi: 6093
PRO: PR:Q13464
Chemistry
GuidetoPHARMACOLOGY: 1503