FZD5 - Frizzled-5 - human protein (Function)
 
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FZD5 »  Frizzled-5  (Fz-5)
 
Protein also known as:  FzE5.
Gene name:  FZD5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 26 1
GENE REF ISO

Function

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Overview 
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway.  
2
  • UniProtKB
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
  • BHF-UCL
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
Wnt-activated receptor activitydefinition[GO:0042813]  
2
  • BHF-UCL
  • RefGenome
Wnt-protein bindingdefinition[GO:0017147]  
3
  • UniProtKB
  • BHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525] silver  
1
  • Ortholog Compara
Anterior/posterior axis specification, embryodefinition[GO:0008595]  
1
  • BHF-UCL
Apoptotic process involved in morphogenesisdefinition[GO:0060561] silver  
1
  • Ortholog Compara
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
1
  • Ortholog Compara
Canonical Wnt signaling pathwaydefinition[GO:0060070]  
3
  • BHF-UCL
Cell maturationdefinition[GO:0048469] silver  
1
  • Ortholog Compara
Cellular response to molecule of bacterial origindefinition[GO:0071219]  
1
  • BHF-UCL
Chorionic trophoblast cell differentiationdefinition[GO:0060718] silver  
1
  • Ortholog Compara
Embryonic axis specificationdefinition[GO:0000578]  
1
  • BHF-UCL
Embryonic camera-type eye developmentdefinition[GO:0031076] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Labyrinthine layer blood vessel developmentdefinition[GO:0060716] silver  
1
  • Ortholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
1
  • Ortholog Compara
Neuron differentiationdefinition[GO:0030182]  
1
  • Ortholog Curator
Non-canonical Wnt signaling pathwaydefinition[GO:0035567]  
1
  • RefGenome
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
1
  • BHF-UCL
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • BHF-UCL
Post-embryonic camera-type eye developmentdefinition[GO:0031077] silver  
1
  • Ortholog Compara
Regulation of canonical Wnt signaling pathwaydefinition[GO:0060828] silver  
1
  • Ortholog Compara
Regulation of chorionic trophoblast cell proliferationdefinition[GO:1901382] silver  
1
  • Ortholog Compara
Regulation of tight junction assemblydefinition[GO:2000810] silver  
1
  • Ortholog Compara
Spemann organizer formationdefinition[GO:0060061]  
1
  • BHF-UCL
Syncytiotrophoblast cell differentiation involved in labyrinthine layer developmentdefinition[GO:0060715] silver  
1
  • Ortholog Compara
T cell differentiation in thymusdefinition[GO:0033077] silver  
1
  • Ortholog Compara
Wnt signaling pathway involved in dorsal/ventral axis specificationdefinition[GO:0044332]  
1
  • BHF-UCL
Enzymatic activity 
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal cell carcinoma  hsa05217+7855  
HTLV-I infection  hsa05166+7855  
Melanogenesis  hsa04916+7855  
Pathways in cancer  hsa05200+7855  
Wnt signaling pathway  hsa04310+7855  
According to Reactome, this protein belongs to the following pathways:
Asymmetric localization of PCP proteins  REACT_172638  
Ca2+ pathway  REACT_172761  
Class B/2 (Secretin family receptors)  REACT_18372  
disassembly of the destruction complex and recruitment of AXIN to the membrane  REACT_200610  
regulation of FZD by ubiquitination  REACT_200716  
RNF mutants show enhanced WNT signaling and proliferation  REACT_228188  
WNT5A-dependent internalization of FZD2, FZD5 and ROR2  REACT_172631  
 

Keywords

Biological process 
Wnt signaling pathway  definition   [KW-0879]
Molecular function 
Developmental protein  definition   [KW-0217]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FZD5
GenomeRNAi: 7855
PRO: PR:Q13467