SMAD4 - Mothers against decapentaplegic homolog 4 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
SMAD4 »  Mothers against decapentaplegic homolog 4  (MAD homolog 4)
 
Protein also known as:  Deletion target in pancreatic carcinoma 4.
Gene name:  SMAD4
Family name: Dwarfin/SMAD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 355 1
GENE REF ISO

Function

 show evidences
Overview 
In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8 (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.  
2
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Collagen bindingdefinition[GO:0005518] silver  
  • IEAOrtholog Compara
Core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000987]  
1
  • IDAUniProtKB
Contributes to DNA bindingdefinition[GO:0003677]  
1
  • IDABHF-UCL
I-SMAD bindingdefinition[GO:0070411]  
1
  • IPIBHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
26
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
  • IPIHGNC
Contributes to protein binding transcription factor activitydefinition[GO:0000988]  
1
  • IDAUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
R-SMAD bindingdefinition[GO:0070412]  
4
  • IPIBHF-UCL
RNA polymerase II transcription factor bindingdefinition[GO:0001085] silver  
  • IEAOrtholog Compara
RNA polymerase II transcription factor binding transcription factor activitydefinition[GO:0001076] silver  
  • IEAOrtholog Compara
Contributes to sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDABHF-UCL
Contributes to sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDABHF-UCL
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDABHF-UCL
Transforming growth factor beta receptor, common-partner cytoplasmic mediator activitydefinition[GO:0030616]  
1
  • IDABHF-UCL
GO biological process 
Atrioventricular canal developmentdefinition[GO:0036302] silver  
  • IEAOrtholog Compara
Atrioventricular valve formationdefinition[GO:0003190] silver  
  • IEAOrtholog Compara
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IDABHF-UCL
Brainstem developmentdefinition[GO:0003360] silver  
  • IEAOrtholog Compara
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658] silver  
  • IEAOrtholog Compara
Cardiac septum developmentdefinition[GO:0003279] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283] silver  
  • IEAOrtholog Compara
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
Endocardial cell differentiationdefinition[GO:0060956] silver  
  • IEAOrtholog Compara
Endoderm developmentdefinition[GO:0007492] silver  
  • IEAOrtholog Compara
Endothelial cell activationdefinition[GO:0042118] silver  
  • IEAOrtholog Compara
Epithelial to mesenchymal transition involved in endocardial cushion formationdefinition[GO:0003198] silver  
  • IEAOrtholog Compara
Formation of anatomical boundarydefinition[GO:0048859] silver  
  • IEAOrtholog Compara
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
  • IEAOrtholog Compara
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IDAGOC
Mesoderm developmentdefinition[GO:0007498] silver  
  • IEAOrtholog Compara
Metanephric mesenchyme morphogenesisdefinition[GO:0072133] silver  
  • IEAOrtholog Compara
Negative regulation of cell deathdefinition[GO:0060548] silver  
  • IEAOrtholog Compara
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of protein catabolic processdefinition[GO:0042177]  
1
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDABHF-UCL
Nephrogenic mesenchyme morphogenesisdefinition[GO:0072134] silver  
  • IEAOrtholog Compara
Neural crest cell differentiationdefinition[GO:0014033] silver  
  • IEAOrtholog Compara
Neuron fate commitmentdefinition[GO:0048663] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
1
  • IMPBHF-UCL
Positive regulation of cell proliferation involved in heart valve morphogenesisdefinition[GO:0003251] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
  • ISSOrtholog Curator
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
  • ISSOrtholog Curator
Positive regulation of SMAD protein import into nucleusdefinition[GO:0060391]  
  • ISSOrtholog Curator
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
5
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0030511]  
1
  • IDABHF-UCL
Regulation of bindingdefinition[GO:0051098] silver  
  • IEAOrtholog Compara
Regulation of hair follicle developmentdefinition[GO:0051797] silver  
  • IEAOrtholog Compara
Regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0017015]  
1
  • IMPBHF-UCL
Regulation of transforming growth factor beta2 productiondefinition[GO:0032909]  
1
  • IMPBHF-UCL
Response to hypoxiadefinition[GO:0001666]  
1
  • IMPBHF-UCL
Response to transforming growth factor betadefinition[GO:0071559]  
1
  • IDAUniProtKB
Sebaceous gland developmentdefinition[GO:0048733] silver  
  • IEAOrtholog Compara
SMAD protein complex assemblydefinition[GO:0007183]  
1
  • IDABHF-UCL
SMAD protein signal transductiondefinition[GO:0060395]  
2
  • IDABHF-UCL
Somite rostral/caudal axis specificationdefinition[GO:0032525] silver  
  • IEAOrtholog Compara
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
2
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+4089  
Cell cycle  hsa04110+4089  
Chronic myeloid leukemia  hsa05220+4089  
Colorectal cancer  hsa05210+4089  
HTLV-I infection  hsa05166+4089  
Pancreatic cancer  hsa05212+4089  
Pathways in cancer  hsa05200+4089  
TGF-beta signaling pathway  hsa04350+4089  
Wnt signaling pathway  hsa04310+4089  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Disease  REACT_116125  
Gene Expression  REACT_71  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links