BIRC3 - Baculoviral IAP repeat-containing protein 3 - human protein (Function)
 
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BIRC3 »  Baculoviral IAP repeat-containing protein 3   [ EC 6.3.2.- ]
 
Protein also known as:  TNFR2-TRAF-signaling complex protein 1.
Gene name:  BIRC3
Family name: IAP
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 127 1
GENE REF ISO

Function

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Overview 
Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Ubiquitin-protein ligase activitydefinition[GO:0004842]  
2
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Necroptotic processdefinition[GO:0070266] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • TASPINC
Negative regulation of necroptotic processdefinition[GO:0060546] silver  
  • IEAOrtholog Compara
Negative regulation of phosphorylationdefinition[GO:0042326] silver  
  • IEAOrtholog Compara
Negative regulation of reactive oxygen species metabolic processdefinition[GO:2000378] silver  
  • IEAOrtholog Compara
NIK/NF-kappaB signalingdefinition[GO:0038061]  
1
  • TASUniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
1
  • TASUniProtKB
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDAUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein ubiquitinationdefinition[GO:0016567]  
2
  • IDAGOC
Regulation of apoptotic processdefinition[GO:0042981]  
1
  • IMPUniProtKB
Regulation of cysteine-type endopeptidase activitydefinition[GO:2000116]  
1
  • TASUniProtKB
Regulation of inflammatory responsedefinition[GO:0050727]  
1
  • TASUniProtKB
Regulation of innate immune responsedefinition[GO:0045088]  
1
  • TASUniProtKB
Regulation of necroptotic processdefinition[GO:0060544]  
1
  • IMPUniProtKB
Regulation of nucleotide-binding oligomerization domain containing signaling pathwaydefinition[GO:0070424]  
1
  • TASUniProtKB
Regulation of RIG-I signaling pathwaydefinition[GO:0039535]  
1
  • TASUniProtKB
Regulation of toll-like receptor signaling pathwaydefinition[GO:0034121]  
1
  • TASUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+330  
Focal adhesion  hsa04510+330  
HTLV-I infection  hsa05166+330  
NOD-like receptor signaling pathway  hsa04621+330  
Pathways in cancer  hsa05200+330  
Small cell lung cancer  hsa05222+330  
Toxoplasmosis  hsa05145+330  
Ubiquitin mediated proteolysis  hsa04120+330  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Ubl conjugation pathway  definition   [KW-0833]
Molecular function 
Ligase  definition   [KW-0436]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links