PICALM - Phosphatidylinositol-binding clathrin assembly protein - human protein (Function)
 
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PICALM »  Phosphatidylinositol-binding clathrin assembly protein
 
Protein also known as:  Clathrin assembly lymphoid myeloid leukemia protein.
Gene name:  PICALM
Family name: PICALM/SNAP91
Entry whose protein(s) existence is based on evidence at protein level
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1 79 5
GENE REF ISO

Function

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Overview 
Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.  
1
  • CuratedUniProtKB
GO molecular function 
1-phosphatidylinositol bindingdefinition[GO:0005545]  
  • ISSOrtholog Curator
Clathrin adaptor activitydefinition[GO:0035615]  
1
  • IMPAlzheimers_University_of_Toronto
Clathrin bindingdefinition[GO:0030276]  
3
  • IPIAlzheimers_University_of_Toronto
  • IDABHF-UCL
  • IDAUniProtKB
  • ISSOrtholog Curator
Clathrin heavy chain bindingdefinition[GO:0032050]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Axonogenesisdefinition[GO:0007409] silver  
  • IEAOrtholog Compara
Cargo loading into vesicledefinition[GO:0035459]  
1
  • IMPAlzheimers_University_of_Toronto
Cell proliferationdefinition[GO:0008283]  
1
  • IMPAlzheimers_University_of_Toronto
Clathrin coat assemblydefinition[GO:0048268]  
1
  • IMPBHF-UCL
Clathrin-mediated endocytosisdefinition[GO:0072583]  
2
  • IMPAlzheimers_University_of_Toronto
Dendrite morphogenesisdefinition[GO:0048813] silver  
  • IEAOrtholog Compara
Endosomal transportdefinition[GO:0016197]  
1
  • IMPBHF-UCL
Hemopoiesisdefinition[GO:0030097] silver  
  • IEAOrtholog Compara
Iron ion homeostasisdefinition[GO:0055072]  
1
  • IMPAlzheimers_University_of_Toronto
Iron ion import into celldefinition[GO:0097459]  
1
  • IMPAlzheimers_University_of_Toronto
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • IMPAlzheimers_University_of_Toronto
Negative regulation of receptor-mediated endocytosisdefinition[GO:0048261]  
1
  • IDABHF-UCL
Positive regulation of beta-amyloid formationdefinition[GO:1902004]  
1
  • IMPAlzheimers_University_of_Toronto
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Protein complex assemblydefinition[GO:0006461]  
1
  • TASPINC
Receptor internalizationdefinition[GO:0031623]  
1
  • IMPBHF-UCL
Receptor-mediated endocytosisdefinition[GO:0006898]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Regulation of endocytosisdefinition[GO:0030100]  
1
  • IMPBHF-UCL
Regulation of neuron deathdefinition[GO:1901214]  
1
  • IMPAlzheimers_University_of_Toronto
Regulation of protein localizationdefinition[GO:0032880]  
1
  • IDABHF-UCL
Vesicle-mediated transportdefinition[GO:0016192]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Membrane Trafficking  REACT_11123  
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PICALM
GenomeRNAi: 8301
PRO: PR:Q13492