MTM1 - Myotubularin - human protein (Function)
 
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MTM1 »  Myotubularin   [ EC 3.1.3.64 ]
 
Gene name:  MTM1
Entry whose protein(s) existence is based on evidence at protein level
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1 76 1
GENE REF ISO

Function

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Overview 
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.  
6
  • CuratedUniProtKB
GO molecular function 
Intermediate filament bindingdefinition[GO:0019215]  
1
  • IDAUniProtKB
Phosphatidylinositol bindingdefinition[GO:0035091]  
1
  • IDAUniProtKB
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activitydefinition[GO:0052629]  
1
  • IDAUniProtKB
Phosphatidylinositol-3-phosphatase activitydefinition[GO:0004438]  
1
  • IDAUniProtKB
Phosphoprotein phosphatase activitydefinition[GO:0004721]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein tyrosine phosphatase activitydefinition[GO:0004725] silver  
  • IEAInterPro 2 GO
GO biological process 
Endosome to lysosome transportdefinition[GO:0008333]  
1
  • IDAUniProtKB
Intermediate filament organizationdefinition[GO:0045109]  
1
  • IMPUniProtKB
Mitochondrion distributiondefinition[GO:0048311]  
1
  • IMPUniProtKB
Mitochondrion morphogenesisdefinition[GO:0070584]  
1
  • IDAUniProtKB
Muscle cell cellular homeostasisdefinition[GO:0046716] silver  
  • IEAOrtholog Compara
Phosphatidylinositol dephosphorylationdefinition[GO:0046856]  
2
  • IDAUniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
1
  • IDAUniProtKB
Protein transportdefinition[GO:0015031]  
  • IEAUniProtKB KW
Regulation of vacuole organizationdefinition[GO:0044088]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.64: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O 1-phosphatidyl-1D-myo-inositol + phosphate.  
  • CuratedUniProtKB
It is regulated in the following manner
Allosterically activated by phosphatidylinositol 5-phosphate (PI5P).  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 39 uM for PI3P
KM 17 uM for PI(3,5)P2

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Myotubularin_1
GenomeRNAi: 4534
PRO: PR:Q13496