SQSTM1 - Sequestosome-1 - human protein (Function)
 
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SQSTM1 »  Sequestosome-1
 
Protein also known as:  Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa.
Gene name:  SQSTM1
Entry whose protein(s) existence is based on evidence at protein level
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1 210 2
GENE REF ISO

Function

 show evidences
Overview 
Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.  
11
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
K63-linked polyubiquitin bindingdefinition[GO:0070530] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
28
  • IPIUniProtKB
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • IDAUniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • IPIUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • NASUniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • TASPINC
SH2 domain bindingdefinition[GO:0042169]  
1
  • IDAUniProtKB
Ubiquitin bindingdefinition[GO:0043130]  
1
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Autophagydefinition[GO:0006914]  
2
  • TASBHF-UCL
  • IMPUniProtKB
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Endosomal transportdefinition[GO:0016197]  
1
  • TASUniProtKB
Immune system processdefinition[GO:0002376]  
  • IEAUniProtKB KW
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASUniProtKB
Macroautophagydefinition[GO:0016236]  
  • ISSOrtholog Curator
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • TASUniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
  • IEAOrtholog Compara
Protein localizationdefinition[GO:0008104]  
1
  • TASUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • NASGOC
Regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043122]  
1
  • IMPUniProtKB
Regulation of Ras protein signal transductiondefinition[GO:0046578]  
1
  • NASUniProtKB
Response to stressdefinition[GO:0006950]  
1
  • TASUniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Osteoclast differentiation  hsa04380+8878  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Autophagy  definition   [KW-0072]
Differentiation  definition   [KW-0221]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Sequestosome_1
GenomeRNAi: 8878
PRO: PR:Q13501