SQSTM1 - Sequestosome-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
SQSTM1 »  Sequestosome-1
 
Protein also known as:  Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa.
Gene name:  SQSTM1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 322 2
GENE REF ISO

Function

 show evidences
Overview 
Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.  
14
  • UniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
K63-linked polyubiquitin bindingdefinition[GO:0070530] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
32
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Protein kinase C bindingdefinition[GO:0005080]  
1
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
1
  • PINC
SH2 domain bindingdefinition[GO:0042169]  
1
  • UniProtKB
Ubiquitin bindingdefinition[GO:0043130]  
1
  • UniProtKB
Zinc ion bindingdefinition[GO:0008270] silver  
1
  • InterPro 2 GO
GO biological process 
Activation of mitophagy in response to mitochondrial depolarizationdefinition[GO:0098779]  
2
  • ParkinsonsUK-UCL
Autophagydefinition[GO:0006914]  
2
  • BHF-UCL
  • UniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Endosomal transportdefinition[GO:0016197]  
1
  • UniProtKB
Immune system processdefinition[GO:0002376]  
1
  • UniProtKB KW
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Macroautophagydefinition[GO:0016236]  
1
  • Ortholog Curator
Mitochondrion degradationdefinition[GO:0000422]  
1
  • ParkinsonsUK-UCL
Positive regulation of macroautophagydefinition[GO:0016239]  
1
  • UniProtKB
Positive regulation of protein phosphorylationdefinition[GO:0001934] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • UniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Protein localizationdefinition[GO:0008104]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • GOC
Regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043122]  
1
  • UniProtKB
Regulation of mitochondrion organizationdefinition[GO:0010821]  
1
  • ParkinsonsUK-UCL
Regulation of Ras protein signal transductiondefinition[GO:0046578]  
1
  • UniProtKB
Response to stressdefinition[GO:0006950]  
1
  • UniProtKB
Ubiquitin-dependent protein catabolic processdefinition[GO:0006511]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Osteoclast differentiation  hsa04380+8878  
According to Reactome, this protein belongs to the following pathways:
Interleukin-1 signaling  REACT_22442  
NF-kB is activated and signals survival  REACT_13696  
NRIF signals cell death from the nucleus  REACT_13643  
p75NTR recruits signalling complexes  REACT_13415  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Autophagy  definition   [KW-0072]
Differentiation  definition   [KW-0221]
Immunity  definition   [KW-0391]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Sequestosome_1
GenomeRNAi: 8878
PRO: PR:Q13501