TRPC3 - Short transient receptor potential channel 3 - human protein (Function)
 
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TRPC3 »  Short transient receptor potential channel 3  (TrpC3)
 
Protein also known as:  Transient receptor protein 3 (TRP-3).
Gene name:  TRPC3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 114 3
GENE REF ISO

Function

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Overview 
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the transient receptor potential ca(2+) channel (trp-cc) family  1.A.4.1.4  
GO molecular function 
Calcium channel activitydefinition[GO:0005262]  
1
  • TASPINC
Inositol 1,4,5 trisphosphate bindingdefinition[GO:0070679]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Store-operated calcium channel activitydefinition[GO:0015279]  
1
  • TASPINC
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • IDAUniProtKB
Calcium ion transportdefinition[GO:0006816]  
1
  • TASPINC
Phototransductiondefinition[GO:0007602]  
1
  • TASPINC
Positive regulation of calcium ion transport into cytosoldefinition[GO:0010524]  
1
  • IDAUniProtKB
Response to ATPdefinition[GO:0033198]  
1
  • IDAUniProtKB
Response to calcium iondefinition[GO:0051592]  
1
  • IDAUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Hemostasis  REACT_604  
Signal Transduction  REACT_111102  
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TRPC3
GenomeRNAi: 7222
PRO: PR:Q13507
Chemistry
GuidetoPHARMACOLOGY: 488