ASAH1 - Acid ceramidase - human protein (Function)
 
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ASAH1 »  Acid ceramidase   [ EC 3.5.1.23 ]  (AC)
 
Protein also known as:  N-acylsphingosine amidohydrolase. Cleaved into:  Acid ceramidase subunit alpha; Acid ceramidase subunit beta.
Gene name:  ASAH1
Family name: Acid ceramidase
Entry whose protein(s) existence is based on evidence at protein level
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1 58 3
GENE REF ISO

Function

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Overview 
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.  
  • CuratedUniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824]  
1
  • TASPINC
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Ceramide metabolic processdefinition[GO:0006672]  
1
  • TASPINC
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.23: N-acylsphingosine + H(2)O a carboxylate + sphingosine.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Lysosome  hsa04142+427  
Metabolic pathways  hsa01100+427  
Sphingolipid metabolism  hsa00600+427  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q13510
Other
GeneWiki: ASAH1
GenomeRNAi: 427
PRO: PR:Q13510