SERINC3 - Serine incorporator 3 - human protein (Function)
 
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Protein
Gene
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SERINC3 »  Serine incorporator 3
 
Protein also known as:  Tumor differentially expressed protein 1.
Gene name:  SERINC3
Family name: TDE1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 19 2
GENE REF ISO

Function

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Overview 
Restriction factor required to restrict infectivity of gammaretroviruses, such as HIV-1: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (PubMed26416733, PubMed26416734).  
3
  • UniProtKB
GO molecular function 
L-serine transmembrane transporter activitydefinition[GO:0015194]  
1
  • RefGenome
GO biological process 
Defense response to virusdefinition[GO:0051607]  
2
  • UniProtKB
Detection of virusdefinition[GO:0009597]  
2
  • UniProtKB
Innate immune responsedefinition[GO:0045087]  
2
  • UniProtKB
L-serine transportdefinition[GO:0015825]  
1
  • RefGenome
Phosphatidylserine metabolic processdefinition[GO:0006658] silver  
1
  • InterPro 2 GO
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaydefinition[GO:1902237] silver  
1
  • Ortholog Compara
Sphingolipid metabolic processdefinition[GO:0006665] silver  
1
  • InterPro 2 GO
 

Keywords

Biological process 
Antiviral defense  definition   [KW-0051]
Immunity  definition   [KW-0391]
Innate immunity  definition   [KW-0399]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SERINC3
GenomeRNAi: 10955
PRO: PR:Q13530