HDAC1 - Histone deacetylase 1 - human protein (Function)
 
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HDAC1 »  Histone deacetylase 1
 
Gene name:  HDAC1
Family name: Histone deacetylase » HD type 1
Entry whose protein(s) existence is based on evidence at protein level
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1 358 1
GENE REF ISO

Function

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Overview 
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.  
7
  • CuratedUniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • IPIUniProtKB
Core promoter bindingdefinition[GO:0001047]  
1
  • IDAUniProtKB
Deacetylase activitydefinition[GO:0019213]  
  • ISSOrtholog Curator
Enzyme bindingdefinition[GO:0019899]  
3
  • IPIUniProtKB
Histone deacetylase activitydefinition[GO:0004407]  
4
  • IMPUniProtKB
  • IDABHF-UCL
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IPIBHF-UCL
NAD-dependent histone deacetylase activity (H3-K14 specific)definition[GO:0032041]  
  • IEAEC 2 GO
NAD-dependent histone deacetylase activity (H3-K18 specific)definition[GO:0097372]  
  • IEAEC 2 GO
NAD-dependent histone deacetylase activity (H3-K9 specific)definition[GO:0046969]  
  • IEAEC 2 GO
NAD-dependent histone deacetylase activity (H4-K16 specific)definition[GO:0046970]  
  • IEAEC 2 GO
Contributes to nucleosomal DNA bindingdefinition[GO:0031492]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
67
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Protein deacetylase activitydefinition[GO:0033558]  
2
  • IMPUniProtKB
Contributes to RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • IDAUniProtKB
Contributes to RNA polymerase II distal enhancer sequence-specific DNA bindingdefinition[GO:0000980]  
1
  • IDAUniProtKB
RNA polymerase II repressing transcription factor bindingdefinition[GO:0001103]  
1
  • IPIBHF-UCL
RNA polymerase II transcription corepressor activitydefinition[GO:0001106]  
1
  • IDABHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription factor bindingdefinition[GO:0008134]  
5
  • IPIBHF-UCL
  • IPIUniProtKB
Transcription regulatory region sequence-specific DNA bindingdefinition[GO:0000976]  
  • ISSOrtholog Curator
GO biological process 
ATP-dependent chromatin remodelingdefinition[GO:0043044]  
1
  • IDAUniProtKB
Chromatin modificationdefinition[GO:0016568]  
1
  • TASUniProtKB
Chromatin remodelingdefinition[GO:0006338]  
2
  • ICBHF-UCL
Circadian regulation of gene expressiondefinition[GO:0032922]  
  • ISSOrtholog Curator
Embryonic digit morphogenesisdefinition[GO:0042733]  
  • ISSOrtholog Curator
Epidermal cell differentiationdefinition[GO:0009913]  
  • ISSOrtholog Curator
Eyelid development in camera-type eyedefinition[GO:0061029]  
  • ISSOrtholog Curator
Fungiform papilla formationdefinition[GO:0061198]  
  • ISSOrtholog Curator
Hair follicle placode formationdefinition[GO:0060789]  
  • ISSOrtholog Curator
Histone deacetylationdefinition[GO:0016575]  
1
  • IMPUniProtKB
Histone H3 deacetylationdefinition[GO:0070932]  
1
  • IDABHF-UCL
Histone H4 deacetylationdefinition[GO:0070933]  
1
  • IDABHF-UCL
Negative regulation by host of viral transcriptiondefinition[GO:0043922]  
1
  • IMPUniProtKB
Negative regulation of androgen receptor signaling pathwaydefinition[GO:0060766]  
1
  • IDABHF-UCL
Negative regulation of apoptotic processdefinition[GO:0043066]  
  • ISSOrtholog Curator
Not  Negative regulation of myotube differentiationdefinition[GO:0010832]  
1
  • IMPBHF-UCL
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
2
  • IMPBHF-UCL
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPUniProtKB
Odontogenesis of dentin-containing toothdefinition[GO:0042475]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPBHF-UCL
Positive regulation of receptor biosynthetic processdefinition[GO:0010870]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Protein deacetylationdefinition[GO:0006476]  
1
  • IDAUniProtKB
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.1.98: Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+3065  
Chronic myeloid leukemia  hsa05220+3065  
Huntington's disease  hsa05016+3065  
Notch signaling pathway  hsa04330+3065  
Pathways in cancer  hsa05200+3065  
According to Reactome, this protein belongs to the following pathways:
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants  REACT_160254  
Constitutive Signaling by NOTCH1 PEST Domain Mutants  REACT_160243  
deactivation of the beta-catenin transactivating complex  REACT_200731  
Downregulation of SMAD2/3:SMAD4 transcriptional activity  REACT_121111  
Factors involved in megakaryocyte development and platelet production  REACT_24970  
formation of the beta-catenin:TCF transactivating complex  REACT_200753  
G0 and Early G1  REACT_111214  
NoRC negatively regulates rRNA expression  REACT_200856  
NOTCH1 Intracellular Domain Regulates Transcription  REACT_118780  
p75NTR negatively regulates cell cycle via SC1  REACT_13695  
RNA Polymerase I Transcription Initiation  REACT_953  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Host-virus interaction  definition   [KW-0945]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Chromatin regulator  definition   [KW-0156]
Hydrolase  definition   [KW-0378]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q13547
Other
GeneWiki: HDAC1
GenomeRNAi: 3065
PRO: PR:Q13547
Chemistry
GuidetoPHARMACOLOGY: 2658