CAMK2B - Calcium/calmodulin-dependent protein kinase type II subunit beta - human protein (Function)
 
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CAMK2B »  Calcium/calmodulin-dependent protein kinase type II subunit beta
 
Gene name:  CAMK2B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.  
1
  • CuratedUniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
  • IEAUniProtKB KW
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • IEAEC 2 GO
GO biological process 
Activation of meiosis involved in egg activationdefinition[GO:0060466] silver  
  • IEAOrtholog Compara
Calcium ion transportdefinition[GO:0006816] silver  
  • IEAOrtholog Compara
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Inhibitory G-protein coupled receptor phosphorylationdefinition[GO:0002030] silver  
  • IEAOrtholog Compara
Neuromuscular process controlling balancedefinition[GO:0050885] silver  
  • IEAOrtholog Compara
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic signaling pathwaydefinition[GO:2001235] silver  
  • IEAOrtholog Compara
Positive regulation of dendritic spine morphogenesisdefinition[GO:0061003]  
  • ISSOrtholog Curator
Positive regulation of neuron projection developmentdefinition[GO:0010976]  
  • ISSOrtholog Curator
Positive regulation of synapse maturationdefinition[GO:0090129]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • TASUniProtKB
Regulation of dendritic spine developmentdefinition[GO:0060998]  
1
  • TASUniProtKB
Regulation of long-term neuronal synaptic plasticitydefinition[GO:0048169]  
1
  • TASUniProtKB
Regulation of skeletal muscle adaptationdefinition[GO:0014733]  
1
  • TASUniProtKB
Regulation of synapse structural plasticitydefinition[GO:0051823]  
1
  • TASUniProtKB
Regulation of synaptic transmission, cholinergicdefinition[GO:0032222] silver  
  • IEAOrtholog Compara
Response to cadmium iondefinition[GO:0046686] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.17: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+816  
Cholinergic synapse  hsa04725+816  
Dopaminergic synapse  hsa04728+816  
ErbB signaling pathway  hsa04012+816  
Gastric acid secretion  hsa04971+816  
Glioma  hsa05214+816  
GnRH signaling pathway  hsa04912+816  
Long-term potentiation  hsa04720+816  
Melanogenesis  hsa04916+816  
Neurotrophin signaling pathway  hsa04722+816  
Olfactory transduction  hsa04740+816  
Oocyte meiosis  hsa04114+816  
Tuberculosis  hsa05152+816  
Wnt signaling pathway  hsa04310+816  
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of CaMKII  REACT_20642  
CREB phosphorylation through the activation of Ras  REACT_20568  
HSF1-dependent transactivation  REACT_200775  
Interferon gamma signaling  REACT_25078  
Ras activation uopn Ca2+ infux through NMDA receptor  REACT_20546  
Trafficking of AMPA receptors  REACT_18307  
Unblocking of NMDA receptor, glutamate binding and activation  REACT_20594  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CAMK2B
GenomeRNAi: 816
PRO: PR:Q13554
Chemistry
GuidetoPHARMACOLOGY: 1556