CAMK2G - Calcium/calmodulin-dependent protein kinase type II subunit gamma - human protein (Function)
 
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CAMK2G »  Calcium/calmodulin-dependent protein kinase type II subunit gamma   [ EC 2.7.11.17 ]  (CaMK-II subunit gamma)
 
Gene name:  CAMK2G
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.  
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  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium-dependent protein serine/threonine phosphatase activitydefinition[GO:0004723]  
1
  • NASUniProtKB
Calmodulin bindingdefinition[GO:0005516]  
1
  • NASUniProtKB
Calmodulin-dependent protein kinase activitydefinition[GO:0004683]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Calcium ion transportdefinition[GO:0006816] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Dephosphorylationdefinition[GO:0016311]  
1
  • NASGOC
G1/S transition of mitotic cell cycledefinition[GO:0000082] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073]  
1
  • NASUniProtKB
Nervous system developmentdefinition[GO:0007399]  
  • IEAUniProtKB KW
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • TASUniProtKB
Regulation of relaxation of cardiac muscledefinition[GO:1901897] silver  
  • IEAOrtholog Compara
Regulation of skeletal muscle adaptationdefinition[GO:0014733]  
1
  • TASUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.17: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+818  
Cholinergic synapse  hsa04725+818  
Dopaminergic synapse  hsa04728+818  
ErbB signaling pathway  hsa04012+818  
Gastric acid secretion  hsa04971+818  
Glioma  hsa05214+818  
GnRH signaling pathway  hsa04912+818  
Long-term potentiation  hsa04720+818  
Melanogenesis  hsa04916+818  
Neurotrophin signaling pathway  hsa04722+818  
Olfactory transduction  hsa04740+818  
Oocyte meiosis  hsa04114+818  
Tuberculosis  hsa05152+818  
Wnt signaling pathway  hsa04310+818  
According to Reactome, this protein belongs to the following pathways:
Immune System  REACT_6900  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CAMK2G
GenomeRNAi: 818
PRO: PR:Q13555
Chemistry
GuidetoPHARMACOLOGY: 1557