NEUROD1 - Neurogenic differentiation factor 1 - human protein (Function)
 
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Protein
Gene
References

 
NEUROD1 »  Neurogenic differentiation factor 1  (NeuroD)
 
Protein also known as:  Class A basic helix-loop-helix protein 3 (bHLHa3).
Gene name:  NEUROD1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).  
1
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682]  
1
  • Ortholog Curator
Double-stranded DNA bindingdefinition[GO:0003690] silver  
1
  • Ortholog Compara
E-box bindingdefinition[GO:0070888]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • UniProtKB
  • BHF-UCL
RNA polymerase II activating transcription factor bindingdefinition[GO:0001102]  
1
  • BHF-UCL
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978] silver  
1
  • Ortholog Compara
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077] silver  
1
  • Ortholog Compara
RNA polymerase II transcription coactivator activitydefinition[GO:0001105]  
1
  • BHF-UCL
Contributes to sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • BHF-UCL
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • BHF-UCL
Transcription coactivator activitydefinition[GO:0003713]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
2
  • BHF-UCL
GO biological process 
Amacrine cell differentiationdefinition[GO:0035881]  
1
  • Ortholog Curator
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
1
  • Ortholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Cerebellum developmentdefinition[GO:0021549]  
1
  • Ortholog Curator
Dentate gyrus developmentdefinition[GO:0021542]  
1
  • Ortholog Curator
Embryonic organ morphogenesisdefinition[GO:0048562]  
1
  • BHF-UCL
Endocrine pancreas developmentdefinition[GO:0031018]  
2
  • BHF-UCL
  • Ortholog Curator
Enteroendocrine cell differentiationdefinition[GO:0035883]  
1
  • Ortholog Curator
Glucose homeostasisdefinition[GO:0042593]  
1
  • BHF-UCL
Inner ear developmentdefinition[GO:0048839]  
1
  • Ortholog Curator
Insulin secretiondefinition[GO:0030073]  
1
  • BHF-UCL
Negative regulation of JAK-STAT cascadedefinition[GO:0046426] silver  
1
  • Ortholog Compara
Negative regulation of type B pancreatic cell apoptotic processdefinition[GO:2000675]  
1
  • BHF-UCL
Neurogenesisdefinition[GO:0022008]  
1
  • BHF-UCL
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • BHF-UCL
Nucleocytoplasmic transportdefinition[GO:0006913] silver  
1
  • Ortholog Compara
Pancreatic A cell fate commitmentdefinition[GO:0003326] silver  
1
  • Ortholog Compara
Pancreatic PP cell fate commitmentdefinition[GO:0003329] silver  
1
  • Ortholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • Ortholog Curator
Positive regulation of cell differentiationdefinition[GO:0045597]  
1
  • Ortholog Curator
Positive regulation of neuron differentiationdefinition[GO:0045666]  
1
  • Ortholog Curator
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • UniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • BHF-UCL
Positive regulation of transcription regulatory region DNA bindingdefinition[GO:2000679]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Regulation of cell cycle arrestdefinition[GO:0071156]  
1
  • Ortholog Curator
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • BHF-UCL
Regulation of intestinal epithelial structure maintenancedefinition[GO:0060730]  
1
  • Ortholog Curator
Response to drugdefinition[GO:0042493] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749]  
1
  • BHF-UCL
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
1
  • Ortholog Compara
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Maturity onset diabetes of the young  hsa04950+4760  
According to Reactome, this protein belongs to the following pathways:
Regulation of gene expression in beta cells  REACT_13819  
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells  REACT_13650  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: NEUROD1
GenomeRNAi: 4760
PRO: PR:Q13562