STIM1 - Stromal interaction molecule 1 - human protein (Function)
 
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Protein
Gene
References

 
STIM1 »  Stromal interaction molecule 1
 
Gene name:  STIM1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.  
9
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family  1.A.52.1.1  
GO molecular function 
Calcium channel regulator activitydefinition[GO:0005246] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Identical protein bindingdefinition[GO:0042802]  
3
  • IPIIntAct
Microtubule plus-end bindingdefinition[GO:0051010]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIUniProtKB
  • IPIIntAct
Store-operated calcium channel activitydefinition[GO:0015279] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of store-operated calcium channel activitydefinition[GO:0032237]  
1
  • IDAUniProtKB
Detection of calcium iondefinition[GO:0005513]  
1
  • IDAUniProtKB
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • IDAUniProtKB
Regulation of store-operated calcium entrydefinition[GO:2001256] silver  
  • IEAOrtholog Compara
Store-operated calcium entrydefinition[GO:0002115] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Hemostasis  REACT_604  
Immune System  REACT_6900  
Note 
Transfection of STIM1 into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STIM1
GenomeRNAi: 6786
PRO: PR:Q13586