STIM1 - Stromal interaction molecule 1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
STIM1 »  Stromal interaction molecule 1
 
Gene name:  STIM1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 282 2
GENE REF ISO

Function

 show evidences
Overview 
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed15866891, PubMed16005298, PubMed16208375, PubMed16537481, PubMed16733527, PubMed16766533, PubMed16807233, PubMed18854159, PubMed19249086, PubMed22464749, PubMed24069340, PubMed24351972, PubMed24591628, PubMed26322679). Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit ORAI1 (PubMed16208375, PubMed16537481). Involved in enamel formation (PubMed24621671). Activated following interaction with TMEM110/STIMATE, leading to promote STIM1 conformational switch (PubMed26322679).  
16
  • UniProtKB
According to TCDB this is a transporter from family:
the ca(2+) release-activated ca(2+) (crac) channel (crac-c) family  1.A.52.1.1  
GO molecular function 
Calcium channel regulator activitydefinition[GO:0005246]  
1
  • UniProtKB
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
4
  • IntAct
Microtubule plus-end bindingdefinition[GO:0051010]  
1
  • UniProtKB
Protease bindingdefinition[GO:0002020]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
14
  • UniProtKB
  • IntAct
GO biological process 
Activation of store-operated calcium channel activitydefinition[GO:0032237]  
2
  • UniProtKB
Calcium ion transportdefinition[GO:0006816]  
1
  • UniProtKB KW
Detection of calcium iondefinition[GO:0005513]  
1
  • UniProtKB
Enamel mineralizationdefinition[GO:0070166]  
1
  • UniProtKB
Regulation of calcium ion transportdefinition[GO:0051924]  
1
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers  R-HSA-983695  
Elevation of cytosolic Ca2+ levels  R-HSA-139853  
Note 
Transfection of STIM1 into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors.  
2
  • UniProtKB
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STIM1
GenomeRNAi: 6786
PRO: PR:Q13586