SEMA5A - Semaphorin-5A - human protein (Function)
 
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SEMA5A »  Semaphorin-5A
 
Protein also known as:  Semaphorin-F (Sema F).
Gene name:  SEMA5A
Family name: Semaphorin
Entry whose protein(s) existence is based on evidence at protein level
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1 39 1
GENE REF ISO

Function

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Overview 
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.  
4
  • CuratedUniProtKB
GO molecular function 
Axon guidance receptor activitydefinition[GO:0008046] silver  
  • IEAOrtholog Compara
Chondroitin sulfate proteoglycan bindingdefinition[GO:0035373]  
  • ISSOrtholog Curator
Heparan sulfate proteoglycan bindingdefinition[GO:0043395]  
  • ISSOrtholog Curator
Semaphorin receptor bindingdefinition[GO:0030215]  
  • ISSOrtholog Curator
Syndecan bindingdefinition[GO:0045545]  
  • ISSOrtholog Curator
GO biological process 
Axonal fasciculationdefinition[GO:0007413]  
  • ISSOrtholog Curator
Blood vessel endothelial cell proliferation involved in sprouting angiogenesisdefinition[GO:0002043]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • TASPINC
Cell chemotaxisdefinition[GO:0060326]  
  • ISSOrtholog Curator
Cell-cell signalingdefinition[GO:0007267]  
1
  • TASPINC
Diencephalon developmentdefinition[GO:0021536]  
  • ISSOrtholog Curator
Negative regulation of axon extension involved in axon guidancedefinition[GO:0048843]  
  • ISSOrtholog Curator
Negative regulation of cell adhesiondefinition[GO:0007162]  
  • ISSOrtholog Curator
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
  • ISSOrtholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Patterning of blood vesselsdefinition[GO:0001569] silver  
  • IEAOrtholog Compara
Positive chemotaxisdefinition[GO:0050918]  
  • ISSOrtholog Curator
Positive regulation of actin filament depolymerizationdefinition[GO:0030836]  
  • ISSOrtholog Curator
Positive regulation of angiogenesisdefinition[GO:0045766]  
  • ISSOrtholog Curator
Positive regulation of axon extension involved in axon guidancedefinition[GO:0048842]  
  • ISSOrtholog Curator
Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
  • ISSOrtholog Curator
Positive regulation of endothelial cell chemotaxisdefinition[GO:2001028]  
  • ISSOrtholog Curator
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
  • ISSOrtholog Curator
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
  • ISSOrtholog Curator
Signal clusteringdefinition[GO:1990256]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9037  
According to Reactome, this protein belongs to the following pathways:
Developmental Biology  REACT_111045  
Metabolism of proteins  REACT_17015  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SEMA5A
GenomeRNAi: 9037
PRO: PR:Q13591