SEMA5A - Semaphorin-5A - human protein (Function)
 
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SEMA5A »  Semaphorin-5A
 
Protein also known as:  Semaphorin-F (Sema F).
Gene name:  SEMA5A
Family name: Semaphorin
Entry whose protein(s) existence is based on evidence at protein level
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1 43 1
GENE REF ISO

Function

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Overview 
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.  
5
  • UniProtKB
GO molecular function 
Axon guidance receptor activitydefinition[GO:0008046] silver  
1
  • Ortholog Compara
Chondroitin sulfate proteoglycan bindingdefinition[GO:0035373]  
1
  • Ortholog Curator
Heparan sulfate proteoglycan bindingdefinition[GO:0043395]  
1
  • Ortholog Curator
Semaphorin receptor bindingdefinition[GO:0030215]  
1
  • Ortholog Curator
Syndecan bindingdefinition[GO:0045545]  
1
  • Ortholog Curator
GO biological process 
Axonal fasciculationdefinition[GO:0007413]  
1
  • Ortholog Curator
Blood vessel endothelial cell proliferation involved in sprouting angiogenesisdefinition[GO:0002043]  
1
  • Ortholog Curator
Cell adhesiondefinition[GO:0007155]  
1
  • PINC
Cell chemotaxisdefinition[GO:0060326]  
1
  • Ortholog Curator
Cell-cell signalingdefinition[GO:0007267]  
1
  • PINC
Diencephalon developmentdefinition[GO:0021536]  
1
  • Ortholog Curator
Negative regulation of axon extension involved in axon guidancedefinition[GO:0048843]  
1
  • Ortholog Curator
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • Ortholog Curator
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • Ortholog Curator
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Patterning of blood vesselsdefinition[GO:0001569] silver  
1
  • Ortholog Compara
Positive chemotaxisdefinition[GO:0050918]  
1
  • Ortholog Curator
Positive regulation of actin filament depolymerizationdefinition[GO:0030836]  
1
  • Ortholog Curator
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • Ortholog Curator
Positive regulation of axon extension involved in axon guidancedefinition[GO:0048842]  
1
  • Ortholog Curator
Positive regulation of catenin import into nucleusdefinition[GO:0035413]  
1
  • Ortholog Curator
Positive regulation of endothelial cell chemotaxisdefinition[GO:2001028]  
1
  • Ortholog Curator
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • Ortholog Curator
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
1
  • Ortholog Curator
Signal clusteringdefinition[GO:1990256]  
1
  • Ortholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+9037  
According to Reactome, this protein belongs to the following pathways:
O-glycosylation of TSR domain-containing proteins  REACT_264269  
Other semaphorin interactions  REACT_19200  
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SEMA5A
GenomeRNAi: 9037
PRO: PR:Q13591