MTMR1 - Myotubularin-related protein 1 - human protein (Function)
 
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Protein
Gene
References

 
MTMR1 »  Myotubularin-related protein 1
 
Protein also known as:  Phosphatidylinositol-3-phosphate phosphatase [EC 3.1.3.64].
Gene name:  MTMR1
Entry whose protein(s) existence is based on evidence at protein level
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1 29 2
GENE REF ISO

Function

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Overview 
Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol (3,5)-bisphosphate.  
2
  • UniProtKB
GO molecular function 
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activitydefinition[GO:0052629] silver  
1
  • InterPro 2 GO
Phosphatidylinositol-3-phosphatase activitydefinition[GO:0004438]  
2
  • UniProtKB
  • Ortholog Curator
Protein tyrosine phosphatase activitydefinition[GO:0004725] silver  
1
  • InterPro 2 GO
GO biological process 
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
1
  • InterPro 2 GO
Phosphatidylinositol dephosphorylationdefinition[GO:0046856]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.64: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O 1-phosphatidyl-1D-myo-inositol + phosphate.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fructose and mannose metabolism  hsa00051+8776  
According to Reactome, this protein belongs to the following pathway:
Synthesis of PIPs at the plasma membrane  REACT_121025  
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MTMR1
GenomeRNAi: 8776
PRO: PR:Q13613