MTMR2 - Myotubularin-related protein 2 - human protein (Function)
 
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MTMR2 »  Myotubularin-related protein 2   [ EC 3.1.3.- ]
 
Gene name:  MTMR2
Entry whose protein(s) existence is based on evidence at protein level
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1 38 2
GENE REF ISO

Function

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Overview 
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.  
2
  • CuratedUniProtKB
GO molecular function 
Phosphatidylinositol phosphate phosphatase activitydefinition[GO:0052866] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
  • IEAOrtholog Compara
Protein tyrosine phosphatase activitydefinition[GO:0004725] silver  
  • IEAInterPro 2 GO
Protein tyrosine/serine/threonine phosphatase activitydefinition[GO:0008138]  
1
  • NASUniProtKB
GO biological process 
Dendritic spine maintenancedefinition[GO:0097062]  
  • ISSOrtholog Curator
Inositol phosphate dephosphorylationdefinition[GO:0046855] silver  
  • IEAOrtholog Compara
Myelin assemblydefinition[GO:0032288] silver  
  • IEAOrtholog Compara
Negative regulation of endocytosisdefinition[GO:0045806]  
  • ISSOrtholog Curator
Negative regulation of excitatory postsynaptic membrane potentialdefinition[GO:0090394]  
  • ISSOrtholog Curator
Negative regulation of myelinationdefinition[GO:0031642] silver  
  • IEAOrtholog Compara
Negative regulation of receptor catabolic processdefinition[GO:2000645]  
  • ISSOrtholog Curator
Negative regulation of receptor internalizationdefinition[GO:0002091]  
  • ISSOrtholog Curator
Neuron developmentdefinition[GO:0048666] silver  
  • IEAOrtholog Compara
Phosphatidylinositol dephosphorylationdefinition[GO:0046856] silver  
  • IEAOrtholog Compara
Positive regulation of early endosome to late endosome transportdefinition[GO:2000643]  
  • ISSOrtholog Curator
Protein dephosphorylationdefinition[GO:0006470]  
1
  • NASUniProtKB
Protein tetramerizationdefinition[GO:0051262] silver  
  • IEAOrtholog Compara
Enzymatic activity 
It is regulated in the following manner
Interaction with SBF1 increases phosphatase activity.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fructose and mannose metabolism  hsa00051+8898  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MTMR2
GenomeRNAi: 8898
PRO: PR:Q13614