MTMR2 - Myotubularin-related protein 2 - human protein (Function)
 
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MTMR2 »  Myotubularin-related protein 2
 
Protein also known as:  Phosphatidylinositol-3,5-bisphosphate 3-phosphatase [EC 3.1.3.95].
Gene name:  MTMR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.  
4
  • UniProtKB
GO molecular function 
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase activitydefinition[GO:0052629]  
1
  • UniProtKB
Phosphatidylinositol-3-phosphatase activitydefinition[GO:0004438]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
  • IntAct
Protein homodimerization activitydefinition[GO:0042803] silver  
1
  • Ortholog Compara
Protein tyrosine phosphatase activitydefinition[GO:0004725] silver  
1
  • InterPro 2 GO
Protein tyrosine/serine/threonine phosphatase activitydefinition[GO:0008138]  
1
  • UniProtKB
GO biological process 
Dendritic spine maintenancedefinition[GO:0097062]  
1
  • Ortholog Curator
Inositol phosphate dephosphorylationdefinition[GO:0046855] silver  
1
  • Ortholog Compara
Myelin assemblydefinition[GO:0032288] silver  
1
  • Ortholog Compara
Negative regulation of endocytosisdefinition[GO:0045806]  
1
  • Ortholog Curator
Negative regulation of excitatory postsynaptic membrane potentialdefinition[GO:0090394]  
1
  • Ortholog Curator
Negative regulation of myelinationdefinition[GO:0031642] silver  
1
  • Ortholog Compara
Negative regulation of receptor catabolic processdefinition[GO:2000645]  
1
  • Ortholog Curator
Negative regulation of receptor internalizationdefinition[GO:0002091]  
1
  • Ortholog Curator
Neuron developmentdefinition[GO:0048666] silver  
1
  • Ortholog Compara
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
1
  • InterPro 2 GO
Phosphatidylinositol dephosphorylationdefinition[GO:0046856]  
1
  • UniProtKB
Positive regulation of early endosome to late endosome transportdefinition[GO:2000643]  
1
  • Ortholog Curator
Protein dephosphorylationdefinition[GO:0006470]  
1
  • UniProtKB
Protein tetramerizationdefinition[GO:0051262] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 3.1.3.64: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H(2)O 1-phosphatidyl-1D-myo-inositol + phosphate.  
3
  • UniProtKB
EC 3.1.3.95: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H(2)O 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.  
2
  • UniProtKB
It is regulated in the following manner
Interaction with SBF1 increases phosphatase activity.  
2
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Fructose and mannose metabolism  hsa00051+8898  
According to Reactome, this protein belongs to the following pathways:
Synthesis of PIPs at the early endosome membrane  REACT_120756  
Synthesis of PIPs at the late endosome membrane  REACT_120918  
 

Keywords

Biological process 
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MTMR2
GenomeRNAi: 8898
PRO: PR:Q13614