MTMR3 - Myotubularin-related protein 3 - human protein (Function)
 
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MTMR3 »  Myotubularin-related protein 3
 
Gene name:  MTMR3
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphatidylinositol-3-phosphatase activitydefinition[GO:0004438]  
1
  • IDAUniProtKB
Protein serine/threonine phosphatase activitydefinition[GO:0004722]  
1
  • IDAUniProtKB
Protein tyrosine phosphatase activitydefinition[GO:0004725]  
1
  • IDAUniProtKB
GO biological process 
Peptidyl-tyrosine dephosphorylationdefinition[GO:0035335]  
1
  • IDAGOC
  • IEAInterPro 2 GO
  • IEAEC 2 GO
Phosphatidylinositol dephosphorylationdefinition[GO:0046856]  
1
  • IDAUniProtKB
Protein dephosphorylationdefinition[GO:0006470]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.3.48: Protein tyrosine phosphate + H(2)O protein tyrosine + phosphate.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Synthesis of PIPs at the plasma membrane  REACT_121025  
 
More information is available from:
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protein phosphatase  definition   [KW-0904]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: MTMR3
GenomeRNAi: 8897
PRO: PR:Q13615