SLC12A1 - Solute carrier family 12 member 1 - human protein (Function)
 
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SLC12A1 »  Solute carrier family 12 member 1
 
Protein also known as:  Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2.
Gene name:  SLC12A1
Family name: SLC12A transporter
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 2
GENE REF ISO

Function

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Overview 
Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the cation-chloride cotransporter (ccc) family  2.A.30.1.2  
GO molecular function 
Sodium:potassium:chloride symporter activitydefinition[GO:0008511]  
1
  • TASPINC
GO biological process 
Cell deathdefinition[GO:0008219]  
  • IEAUniProtKB KW
Chloride transmembrane transportdefinition[GO:1902476]  
1
  • TASGOC
  • IEAInterPro 2 GO
Chloride transportdefinition[GO:0006821]  
1
  • TASGOC
Ion transmembrane transportdefinition[GO:0034220]  
  • ISSOrtholog Curator
Potassium ion transportdefinition[GO:0006813]  
  • IEAUniProtKB KW
Sodium ion transportdefinition[GO:0006814]  
  • IEAUniProtKB KW
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
It is regulated in the following manner
Activated by WNK3.  
1
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cation-coupled Chloride cotransporters  REACT_19315  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 6557
PRO: PR:Q13621
Chemistry
GuidetoPHARMACOLOGY: 968