DYRK1A - Dual specificity tyrosine-phosphorylation-regulated kinase 1A - human protein (Function)
 
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DYRK1A »  Dual specificity tyrosine-phosphorylation-regulated kinase 1A   [ EC 2.7.12.1 ]
 
Protein also known as:  Dual specificity YAK1-related kinase.
Gene name:  DYRK1A
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
2
  • TASPINC
Protein self-associationdefinition[GO:0043621]  
  • ISSOrtholog Curator
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
  • IEAEC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • ISSOrtholog Curator
Tau protein bindingdefinition[GO:0048156]  
1
  • ISSBHF-UCL
GO biological process 
Circadian rhythmdefinition[GO:0007623]  
  • ISSOrtholog Curator
Negative regulation of DNA damage response, signal transduction by p53 class mediatordefinition[GO:0043518]  
1
  • ISSBHF-UCL
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • ISSBHF-UCL
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAMGI
  • ISSOrtholog Curator
Positive regulation of protein deacetylationdefinition[GO:0090312]  
1
  • ISSBHF-UCL
Protein autophosphorylationdefinition[GO:0046777]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by RANBP9.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DYRK1A
GenomeRNAi: 1859
PRO: PR:Q13627
Chemistry
GuidetoPHARMACOLOGY: 2009