DYRK1A - Dual specificity tyrosine-phosphorylation-regulated kinase 1A - human protein (Function)
 
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DYRK1A »  Dual specificity tyrosine-phosphorylation-regulated kinase 1A   [ EC 2.7.12.1 ]
 
Protein also known as:  Dual specificity YAK1-related kinase.
Gene name:  DYRK1A
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 5
GENE REF ISO

Function

 show evidences
Overview 
May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIBHF-UCL
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
2
  • TASPINC
Protein self-associationdefinition[GO:0043621]  
  • ISSOrtholog Curator
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
  • IEAEC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • ISSOrtholog Curator
Tau protein bindingdefinition[GO:0048156]  
1
  • ISSBHF-UCL
GO biological process 
Circadian rhythmdefinition[GO:0007623]  
  • ISSOrtholog Curator
Negative regulation of DNA damage response, signal transduction by p53 class mediatordefinition[GO:0043518]  
1
  • ISSBHF-UCL
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Peptidyl-threonine phosphorylationdefinition[GO:0018107]  
1
  • ISSBHF-UCL
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAMGI
  • ISSOrtholog Curator
Positive regulation of protein deacetylationdefinition[GO:0090312]  
1
  • ISSBHF-UCL
Protein autophosphorylationdefinition[GO:0046777]  
  • ISSOrtholog Curator
Protein phosphorylationdefinition[GO:0006468]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
4
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by RANBP9. Inhibited by harmine, leucettamine B and leucettine L41.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cell Cycle  REACT_115566  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: DYRK1A
GenomeRNAi: 1859
PRO: PR:Q13627
Chemistry
GuidetoPHARMACOLOGY: 2009