HTR4 - 5-hydroxytryptamine receptor 4 - human protein (Function)
 
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HTR4 »  5-hydroxytryptamine receptor 4  (5-HT4)
 
Protein also known as:  Serotonin receptor 4.
Gene name:  HTR4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 9
GENE REF ISO

Function

 show evidences
Overview 
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.  
  • CuratedUniProtKB
GO molecular function 
Serotonin receptor activitydefinition[GO:0004993]  
1
  • IDAMGI
GO biological process 
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Regulation of appetitedefinition[GO:0032098] silver  
  • IEAInterPro 2 GO
Serotonin receptor signaling pathwaydefinition[GO:0007210]  
2
  • IDAGOC
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+3360  
Neuroactive ligand-receptor interaction  hsa04080+3360  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: 5-HT4_receptor
GenomeRNAi: 3360
PRO: PR:Q13639
Chemistry
GuidetoPHARMACOLOGY: 9