ALKBH1 - Alkylated DNA repair protein alkB homolog 1 - human protein (Function)
 
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ALKBH1 »  Alkylated DNA repair protein alkB homolog 1
 
Gene name:  ALKBH1
Family name: AlkB
Entry whose protein(s) existence is based on evidence at protein level
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1 14 1
GENE REF ISO

Function

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Overview 
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.  
2
  • CuratedUniProtKB
GO molecular function 
Chemoattractant activitydefinition[GO:0042056] silver  
  • IEAOrtholog Compara
DNA-(apurinic or apyrimidinic site) lyase activitydefinition[GO:0003906]  
1
  • IDAUniProtKB
Ferrous iron bindingdefinition[GO:0008198]  
1
  • IDAUniProtKB
Methylcytosine dioxygenase activitydefinition[GO:0070579]  
1
  • IDAUniProtKB
GO biological process 
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
DNA catabolic process, endonucleolyticdefinition[GO:0000737]  
1
  • IDAGOC
  • IEAEC 2 GO
DNA dealkylation involved in DNA repairdefinition[GO:0006307]  
1
  • IDAUniProtKB
DNA demethylationdefinition[GO:0080111]  
1
  • IDAUniProtKB
DNA repairdefinition[GO:0006281]  
2
  • IDAUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Neuron migrationdefinition[GO:0001764] silver  
  • IEAOrtholog Compara
Neuron projection developmentdefinition[GO:0031175] silver  
  • IEAOrtholog Compara
Oxidative demethylationdefinition[GO:0070989]  
1
  • IDAUniProtKB
Placenta developmentdefinition[GO:0001890] silver  
  • IEAOrtholog Compara
Positive chemotaxisdefinition[GO:0050918] silver  
  • IEAOrtholog Compara
RNA repairdefinition[GO:0042245]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 4.2.99.18: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.  
  • CuratedUniProtKB
EC 1.14.11.33: DNA-base-CH(3) + 2-oxoglutarate + O(2) DNA-base + formaldehyde + succinate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 Fe(2+) ion per subunit.  
1
  • CuratedUniProtKB
Caution 
Detected in cytoplasm and nucleus When expressed as fusion protein with an N-terminal tag, or when the first 26 N-terminal residues are removed (PubMed17979886 and PubMed18603530). The endogenous, unmodified protein localizes to mitochondria (PubMed18603530).  
2
  • CuratedUniProtKB
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
RNA repair  definition   [KW-0692]
Molecular function 
Dioxygenase  definition   [KW-0223]
Lyase  definition   [KW-0456]
Oxidoreductase  definition   [KW-0560]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 8846
PRO: PR:Q13686