CACNA1S - Voltage-dependent L-type calcium channel subunit alpha-1S - human protein (Function)
 
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CACNA1S »  Voltage-dependent L-type calcium channel subunit alpha-1S
 
Protein also known as:  Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle.
Gene name:  CACNA1S
Entry whose protein(s) existence is based on evidence at protein level
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1 56 1
GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.  
  • CuratedUniProtKB
GO molecular function 
High voltage-gated calcium channel activitydefinition[GO:0008331]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • IDAUniProtKB
GO biological process 
Calcium ion importdefinition[GO:0070509] silver  
  • IBARefGenome
Calcium ion transportdefinition[GO:0006816]  
1
  • IDAUniProtKB
Endoplasmic reticulum organizationdefinition[GO:0007029] silver  
  • IEAOrtholog Compara
Extraocular skeletal muscle developmentdefinition[GO:0002074] silver  
  • IEAOrtholog Compara
Membrane depolarization during action potentialdefinition[GO:0086010] silver  
  • IBARefGenome
Muscle contractiondefinition[GO:0006936]  
1
  • IMPUniProtKB
Myoblast fusiondefinition[GO:0007520] silver  
  • IEAOrtholog Compara
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Regulation of ion transmembrane transportdefinition[GO:0034765]  
  • IEAUniProtKB KW
Skeletal muscle adaptationdefinition[GO:0043501] silver  
  • IEAOrtholog Compara
Skeletal muscle fiber developmentdefinition[GO:0048741] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501] silver  
  • IEAOrtholog Compara
Striated muscle contractiondefinition[GO:0006941] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+779  
Arrhythmogenic right ventricular cardiomyopathy (ARVC)  hsa05412+779  
Calcium signaling pathway  hsa04020+779  
Cardiac muscle contraction  hsa04260+779  
Cholinergic synapse  hsa04725+779  
Dilated cardiomyopathy  hsa05414+779  
GABAergic synapse  hsa04727+779  
GnRH signaling pathway  hsa04912+779  
Hypertrophic cardiomyopathy (HCM)  hsa05410+779  
MAPK signaling pathway  hsa04010+779  
Vascular smooth muscle contraction  hsa04270+779  
According to Reactome, this protein belongs to the following pathway:
NCAM1 interactions  REACT_18312  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cav1.1
GenomeRNAi: 779
PRO: PR:Q13698
Chemistry
GuidetoPHARMACOLOGY: 528