RAPSN - 43 kDa receptor-associated protein of the synapse - human protein (Sequence)
 
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Protein
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RAPSN »  43 kDa receptor-associated protein of the synapse  (RAPsyn)
 
Protein also known as:  Acetylcholine receptor-associated 43 kDa protein.
Gene name:  RAPSN
Family name: RAPsyn
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   412 aaMass: 46328 Da,  pI: 8.48
MGQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV TAHSEMGRYK EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAGAQ LGGQVSLSMG NAFLGLSVFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE KALFFPCKAA ELVNNYGKGW SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQALL GVAKCWVARK ALDKALDAIE RAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV RFHECVEETE LYCGLCGESI GEKNSRLQAL PCSHIFHLRC LQNNGTRSCP NCRRSSMKPG FV

Sequence

 show evidences
Domain 
A cysteine-rich region homologous to part of the regulatory domain of protein kinase C may be important in interactions of this protein with the lipid bilayer.  
  • CuratedUniProtKB
PTM 
Ubiquitinated by the BCR(KLHL8) complex, leading to its degradation.  
1
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Repeat  definition   [KW-0677]
TPR repeat  definition   [KW-0802]
Zinc-finger  definition   [KW-0863]
PTM 
Lipoprotein  definition   [KW-0449]
Myristate  definition   [KW-0519]
Phosphoprotein  definition   [KW-0597]
Ubl conjugation  definition   [KW-0832]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
Gene3D: 3.30.40.10
Gene3D: 1.25.40.10
InterPro: IPR011990 [ TPR-like helical ]
InterPro: IPR001440 [ TPR 1 ]
InterPro: IPR001237 [ Postsynaptic ]
InterPro: IPR019734 [ TPR repeat ]
InterPro: IPR001841 [ Znf RING ]
InterPro: IPR019568 [ Rapsyn myristoylation/link N ]
InterPro: IPR018293 [ Postsynaptic CS ]
InterPro: IPR013083 [ Znf RING/FYVE/PHD ]
InterPro: IPR013026 [ TPR-contain dom ]
PANTHER: PTHR10098:SF16 [ PTHR10098:SF16 ]
Pfam: PF10579 [ Rapsyn N ]
Pfam: PF13181 [ TPR 8 ]
Pfam: PF13639 [ zf-RING 2 ]
Pfam: PF00515 [ TPR 1 ]
PRINTS: PR00217 [ POSTSYNAPTIC ]
PROSITE: PS00405 [ 43 KD POSTSYNAPTIC ]
PROSITE: PS50005 [ TPR ]
PROSITE: PS50089 [ ZF RING 2 ]
PROSITE: PS50293 [ TPR REGION ]
SMART: SM00028 [ TPR ]
SMART: SM00184 [ RING ]
Genome annotation databases
Ensembl: Transcript: ENST00000298854;  Protein: ENSP00000298854;  Gene: ENSG00000165917.
Ensembl: Transcript: ENST00000352508;  Protein: ENSP00000298853;  Gene: ENSG00000165917.
Ensembl: Transcript: ENST00000524487;  Protein: ENSP00000435551;  Gene: ENSG00000165917.
Ensembl: Transcript: ENST00000529341;  Protein: ENSP00000431732;  Gene: ENSG00000165917.
KEGG: hsa:5913
UCSC: uc001nfj.2
UCSC: uc001nfi.2
Organism-specific databases
MGI: MGI:99422 [ Rapsn ]
PTM databases
PhosphoSite: Q13702
Phylogenomic databases
eggNOG: COG0457
HOGENOM: HOG000231395
HOVERGEN: HBG061484
InParanoid: Q13702
OMA: EEMELYC
PhylomeDB: Q13702
Sequence databases
CCDS: CCDS7937.1 [ Q13702-2 ]
CCDS: CCDS7936.1 [ Q13702-1 ]
EMBL: mRNA:  Z33905 . Translation:  CAA83954.1 .
EMBL: mRNA:  BC004196 . Translation:  AAH04196.1 .
EMBL: Genomic DNA:  CH471064 . Translation:  EAW67914.1 .
EMBL: mRNA:  AF449218 . Translation:  AAL86639.1 .
IPI: IPI00013319
IPI: IPI00828059
PIR: S45064
RefSeq: Protein:  NP_005046.2. Nucleotide sequence:  NM_005055.4.
RefSeq: Protein:  NP_116034.2. Nucleotide sequence:  NM_032645.4.
UniProtKB: Q13702 [ RAPSN ]