ACVR2B - Activin receptor type-2B - human protein (Function)
 
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ACVR2B »  Activin receptor type-2B   [ EC 2.7.11.30 ]
 
Protein also known as:  Activin receptor type IIB (ACTR-IIB).
Gene name:  ACVR2B
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.  
1
  • CuratedUniProtKB
GO molecular function 
Activin bindingdefinition[GO:0048185] silver  
  • IEAOrtholog Compara
Contributes to activin receptor activity, type IIdefinition[GO:0016362]  
1
  • TASHGNC
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Growth factor bindingdefinition[GO:0019838]  
1
  • IPIHGNC
Inhibin bindingdefinition[GO:0034711] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
  • IPIHGNC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IMPHGNC
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712] silver  
  • IEAOrtholog Compara
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAInterPro 2 GO
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
  • IEAInterPro 2 GO
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147] silver  
  • IEAOrtholog Compara
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • TASGOC
Anterior/posterior pattern specificationdefinition[GO:0009952]  
1
  • IMPHGNC
Artery developmentdefinition[GO:0060840]  
  • ISSOrtholog Curator
Blood vessel remodelingdefinition[GO:0001974]  
  • ISSOrtholog Curator
BMP signaling pathwaydefinition[GO:0030509]  
2
  • IMPBHF-UCL
Determination of left/right symmetrydefinition[GO:0007368] silver  
  • IEAOrtholog Compara
Embryonic foregut morphogenesisdefinition[GO:0048617] silver  
  • IEAOrtholog Compara
Gastrulation with mouth forming seconddefinition[GO:0001702] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Lymphangiogenesisdefinition[GO:0001946]  
  • ISSOrtholog Curator
Lymphatic endothelial cell differentiationdefinition[GO:0060836]  
  • ISSOrtholog Curator
Mesoderm developmentdefinition[GO:0007498] silver  
  • IEAOrtholog Compara
Odontogenesis of dentin-containing toothdefinition[GO:0042475] silver  
  • IEAOrtholog Compara
Organ growthdefinition[GO:0035265] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Pancreas developmentdefinition[GO:0031016] silver  
  • IEAOrtholog Compara
Positive regulation of activin receptor signaling pathwaydefinition[GO:0032927]  
1
  • IDAHGNC
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IMPBHF-UCL
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • IDAHGNC
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Retina vasculature development in camera-type eyedefinition[GO:0061298]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IDAHGNC
Signal transduction by phosphorylationdefinition[GO:0023014]  
  • IEAInterPro 2 GO
Skeletal system morphogenesisdefinition[GO:0048705] silver  
  • IEAOrtholog Compara
Transmembrane receptor protein serine/threonine kinase signaling pathwaydefinition[GO:0007178]  
1
  • TASPINC
Venous blood vessel developmentdefinition[GO:0060841]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+93  
TGF-beta signaling pathway  hsa04350+93  
According to Reactome, this protein belongs to the following pathways:
Regulation of signaling by NODAL  REACT_111059  
Signaling by Activin  REACT_150238  
Signaling by BMP  REACT_12034  
Signaling by NODAL  REACT_111057  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACVR2B
GenomeRNAi: 93
PRO: PR:Q13705
Chemistry
GuidetoPHARMACOLOGY: 1792