ATP1A4 - Sodium/potassium-transporting ATPase subunit alpha-4 - human protein (Function)
 
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ATP1A4 »  Sodium/potassium-transporting ATPase subunit alpha-4   [ EC 3.6.3.9 ]  (Na(+)/K(+) ATPase alpha-4 subunit)
 
Protein also known as:  Sodium pump subunit alpha-4.
Gene name:  ATP1A4
Entry whose protein(s) existence is based on evidence at protein level
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1 29 2
GENE REF ISO

Function

 show evidences
Overview 
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Sodium:potassium-exchanging ATPase activitydefinition[GO:0005391]  
1
  • TASUniProtKB
GO biological process 
ATP biosynthetic processdefinition[GO:0006754] silver  
  • IEAInterPro 2 GO
ATP hydrolysis coupled proton transportdefinition[GO:0015991]  
1
  • TASUniProtKB
Fertilizationdefinition[GO:0009566] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • TASUniProtKB
Regulation of cellular pHdefinition[GO:0030641]  
1
  • IDAUniProtKB
Regulation of membrane potentialdefinition[GO:0042391] silver  
  • IEAOrtholog Compara
Sodium ion transmembrane transportdefinition[GO:0035725]  
1
  • TASGOC
Sodium ion transportdefinition[GO:0006814]  
1
  • TASUniProtKB
Sperm motilitydefinition[GO:0030317]  
1
  • IDAUniProtKB
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.9: ATP + H(2)O + Na(+)(In) + K(+)(Out) ADP + phosphate + Na(+)(Out) + K(+)(In).  
  • CuratedUniProtKB
It is regulated in the following manner
Specifically inhibited by an endogenous cardiac glycoside, ouabain.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Aldosterone-regulated sodium reabsorption  hsa04960+480  
Bile secretion  hsa04976+480  
Carbohydrate digestion and absorption  hsa04973+480  
Cardiac muscle contraction  hsa04260+480  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+480  
Gastric acid secretion  hsa04971+480  
Mineral absorption  hsa04978+480  
Pancreatic secretion  hsa04972+480  
Protein digestion and absorption  hsa04974+480  
Proximal tubule bicarbonate reclamation  hsa04964+480  
Salivary secretion  hsa04970+480  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Sodium transport  definition   [KW-0739]
Sodium/potassium transport  definition   [KW-0740]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP1A4
GenomeRNAi: 480
PRO: PR:Q13733