RUNX3 - Runt-related transcription factor 3 - human protein (Function)
 
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References

 
RUNX3 »  Runt-related transcription factor 3
 
Protein also known as:  Polyomavirus enhancer-binding protein 2 alpha C subunit (PEA2-alpha C).
Gene name:  RUNX3
Entry whose protein(s) existence is based on evidence at protein level
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1 241 2
GENE REF ISO

Function

 show evidences
Overview 
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed20599712).  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • Ortholog Curator
RNA polymerase II transcription factor activity, sequence-specific DNA bindingdefinition[GO:0000981]  
2
  • Ortholog Curator
  • RefGenome
Transcription factor activity, sequence-specific DNA bindingdefinition[GO:0003700]  
1
  • PINC
GO biological process 
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • RefGenome
Hemopoiesisdefinition[GO:0030097]  
1
  • RefGenome
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • Ortholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • Ortholog Curator
Neuron differentiationdefinition[GO:0030182]  
1
  • RefGenome
Ossificationdefinition[GO:0001503]  
1
  • RefGenome
Peripheral nervous system neuron developmentdefinition[GO:0048935]  
1
  • BHF-UCL
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • UniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of cell differentiationdefinition[GO:0045595]  
1
  • RefGenome
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • RefGenome
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • UniProtKB
Response to transforming growth factor betadefinition[GO:0071559]  
1
  • UniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • PINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RUNX3
GenomeRNAi: 864
PRO: PR:Q13761