RUNX3 - Runt-related transcription factor 3 - human protein (Function)
 
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RUNX3 »  Runt-related transcription factor 3
 
Protein also known as:  Polyomavirus enhancer-binding protein 2 alpha C subunit (PEA2-alpha C).
Gene name:  RUNX3
Entry whose protein(s) existence is based on evidence at protein level
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1 187 2
GENE REF ISO

Function

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Overview 
CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
  • ISSOrtholog Curator
Sequence-specific DNA binding RNA polymerase II transcription factor activitydefinition[GO:0000981]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
Cell maturationdefinition[GO:0048469] silver  
  • IEAOrtholog Compara
Chondrocyte differentiationdefinition[GO:0002062] silver  
  • IEAOrtholog Compara
Hair follicle morphogenesisdefinition[GO:0031069] silver  
  • IEAOrtholog Compara
Interferon-gamma productiondefinition[GO:0032609] silver  
  • IEAOrtholog Compara
Negative regulation of cell cycledefinition[GO:0045786]  
  • ISSOrtholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Peripheral nervous system neuron developmentdefinition[GO:0048935]  
1
  • TASBHF-UCL
Positive regulation of extrinsic apoptotic signaling pathwaydefinition[GO:2001238] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • NASUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RUNX3
GenomeRNAi: 864
PRO: PR:Q13761