APOF - Apolipoprotein F - human protein (Function)
 
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APOF »  Apolipoprotein F  (Apo-F)
 
Protein also known as:  Lipid transfer inhibitor protein (LTIP).
Gene name:  APOF
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII.  
2
  • UniProtKB
GO molecular function 
Cholesterol bindingdefinition[GO:0015485]  
1
  • PINC
Lipid transporter activitydefinition[GO:0005319]  
1
  • PINC
Receptor bindingdefinition[GO:0005102]  
1
  • PINC
GO biological process 
Cholesterol effluxdefinition[GO:0033344] silver  
1
  • Ortholog Compara
Cholesterol metabolic processdefinition[GO:0008203] silver  
1
  • Ortholog Compara
Lipid metabolic processdefinition[GO:0006629]  
1
  • PINC
Lipid transportdefinition[GO:0006869]  
1
  • PINC
Triglyceride metabolic processdefinition[GO:0006641] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
LDL-mediated lipid transport  REACT_6934  
Orphan transporters  REACT_267716  
 

Keywords

Biological process 
Cholesterol metabolism  definition   [KW-0153]
Lipid metabolism  definition   [KW-0443]
Lipid transport  definition   [KW-0445]
Steroid metabolism  definition   [KW-0753]
Sterol metabolism  definition   [KW-1207]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: APOF
GenomeRNAi: 319
PRO: PR:Q13790