AUH - Methylglutaconyl-CoA hydratase, mitochondrial - human protein (Function)
 
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Protein
Gene
References

 
AUH »  Methylglutaconyl-CoA hydratase, mitochondrial
 
Gene name:  AUH
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl-CoA. Has very low enoyl-CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs.  
4
  • CuratedUniProtKB
GO molecular function 
Enoyl-CoA hydratase activitydefinition[GO:0004300]  
1
  • IDAUniProtKB
mRNA 3'-UTR bindingdefinition[GO:0003730]  
1
  • IDAUniProtKB
GO biological process 
Leucine catabolic processdefinition[GO:0006552]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.18: (S)-3-hydroxy-3-methylglutaryl-CoA trans-3-methylglutaconyl-CoA + H(2)O.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+549  
Valine, leucine and isoleucine degradation  hsa00280+549  
According to Reactome, this protein belongs to the following pathway:
Branched-chain amino acid catabolism  REACT_197  
 
More information is available from:
 

Keywords

Biological process 
Branched-chain amino acid catabolism  definition   [KW-0101]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q13825
Other
GenomeRNAi: 549
PRO: PR:Q13825