TNFAIP1 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 - human protein (Function)
 
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TNFAIP1 »  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
 
Protein also known as:  Tumor necrosis factor, alpha-induced protein 1, endothelial.
Gene name:  TNFAIP1
Family name: BACURD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 1
GENE REF ISO

Function

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Overview 
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.  
2
  • CuratedUniProtKB
GO molecular function 
GTP-Rho bindingdefinition[GO:0017049]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
  • IEAOrtholog Compara
Contributes to ubiquitin-protein ligase activitydefinition[GO:0004842]  
1
  • IDAUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • TASUniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • IMPUniProtKB
DNA replicationdefinition[GO:0006260]  
  • ISSOrtholog Curator
Embryo developmentdefinition[GO:0009790]  
  • ISSOrtholog Curator
Immune responsedefinition[GO:0006955]  
1
  • IEPUniProtKB
Negative regulation of Rho protein signal transductiondefinition[GO:0035024]  
1
  • IMPUniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
  • IEAOrtholog Compara
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • IDAUniProtKB
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAInterPro 2 GO
Protein ubiquitinationdefinition[GO:0016567]  
1
  • IDAUniProtKB
Stress fiber assemblydefinition[GO:0043149]  
1
  • IMPUniProtKB
Pathways 
This protein is involved in the following pathway
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TNFAIP1
GenomeRNAi: 7126
PRO: PR:Q13829