TNFAIP1 - BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 - human protein (Function)
 
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TNFAIP1 »  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
 
Protein also known as:  Tumor necrosis factor, alpha-induced protein 1, endothelial.
Gene name:  TNFAIP1
Family name: BACURD
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 37 2
GENE REF ISO

Function

 show evidences
Overview 
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.  
3
  • UniProtKB
GO molecular function 
GTP-Rho bindingdefinition[GO:0017049]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Protein domain specific bindingdefinition[GO:0019904] silver  
1
  • Ortholog Compara
Contributes to ubiquitin-protein transferase activitydefinition[GO:0004842]  
1
  • UniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB
Cell migrationdefinition[GO:0016477]  
1
  • UniProtKB
DNA replicationdefinition[GO:0006260]  
1
  • Ortholog Curator
Embryo developmentdefinition[GO:0009790]  
1
  • Ortholog Curator
Immune responsedefinition[GO:0006955]  
1
  • UniProtKB
Negative regulation of Rho protein signal transductiondefinition[GO:0035024]  
1
  • UniProtKB
Positive regulation of DNA replicationdefinition[GO:0045740] silver  
1
  • Ortholog Compara
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • UniProtKB
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Protein ubiquitinationdefinition[GO:0016567]  
2
  • UniProtKB
  • UniPathway
Stress fiber assemblydefinition[GO:0043149]  
1
  • UniProtKB
Pathways 
This protein is involved in the following pathway
Protein modification; protein ubiquitination  
1
  • UniProtKB
 

Keywords

Biological process 
Ubl conjugation pathway  definition   [KW-0833]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TNFAIP1
GenomeRNAi: 7126
PRO: PR:Q13829