BLMH - Bleomycin hydrolase - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
BLMH »  Bleomycin hydrolase   [ EC 3.4.22.40 ]  (BH)
 
Gene name:  BLMH
Family name: Peptidase C1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 1
GENE REF ISO

Function

 show evidences
Overview 
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Aminopeptidase activitydefinition[GO:0004177]  
1
  • TASPINC
Carboxypeptidase activitydefinition[GO:0004180]  
1
  • TASPINC
Cysteine-type endopeptidase activitydefinition[GO:0004197] silver  
  • IEAInterPro 2 GO
Cysteine-type peptidase activitydefinition[GO:0008234]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Proteolysisdefinition[GO:0006508]  
  • IEAUniProtKB KW
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.22.40: Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Antigen processing: Ubiquitination & Proteasome degradation  REACT_75842  
 

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Protease  definition   [KW-0645]
Thiol protease  definition   [KW-0788]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: Q13867
Other
GeneWiki: BLMH
GeneWiki: Bleomycin_hydrolase
GenomeRNAi: 642
PRO: PR:Q13867