BMPR2 - Bone morphogenetic protein receptor type-2 - human protein (Function)
 
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BMPR2 »  Bone morphogenetic protein receptor type-2
 
Gene name:  BMPR2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 49 2
GENE REF ISO

Function

 show evidences
Overview 
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Growth factor bindingdefinition[GO:0019838] silver  
  • IEAOrtholog Compara
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
5
  • IPIIntAct
  • IPIBHF-UCL
Receptor signaling protein serine/threonine kinase activitydefinition[GO:0004702] silver  
  • IEAInterPro 2 GO
Transforming growth factor beta-activated receptor activitydefinition[GO:0005024] silver  
  • IEAInterPro 2 GO
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952]  
  • ISSOrtholog Curator
Artery developmentdefinition[GO:0060840]  
  • ISSOrtholog Curator
Blood vessel remodelingdefinition[GO:0001974]  
  • ISSOrtholog Curator
BMP signaling pathwaydefinition[GO:0030509]  
4
  • IMPBHF-UCL
  • IMPAgBase
  • ISSOrtholog Curator
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cellular response to starvationdefinition[GO:0009267]  
1
  • IEPBHF-UCL
Chondrocyte developmentdefinition[GO:0002063]  
1
  • IMPAgBase
Lung alveolus developmentdefinition[GO:0048286]  
  • ISSOrtholog Curator
Lymphangiogenesisdefinition[GO:0001946]  
  • ISSOrtholog Curator
Lymphatic endothelial cell differentiationdefinition[GO:0060836]  
  • ISSOrtholog Curator
Mesoderm formationdefinition[GO:0001707]  
  • ISSOrtholog Curator
Negative regulation of cell growthdefinition[GO:0030308]  
1
  • IDAUniProtKB
Negative regulation of chondrocyte proliferationdefinition[GO:1902731]  
1
  • IMPAgBase
Negative regulation of DNA biosynthetic processdefinition[GO:2000279]  
1
  • IMPBHF-UCL
Negative regulation of systemic arterial blood pressuredefinition[GO:0003085]  
1
  • IMPBHF-UCL
Negative regulation of vasoconstrictiondefinition[GO:0045906]  
  • ISSOrtholog Curator
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
1
  • IMPUniProtKB
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IMPBHF-UCL
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IMPUniProtKB
Positive regulation of endothelial cell proliferationdefinition[GO:0001938]  
1
  • IMPUniProtKB
Positive regulation of epithelial cell migrationdefinition[GO:0010634]  
1
  • IDAUniProtKB
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IMPBHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
2
  • IMPBHF-UCL
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • IMPHGNC
Regulation of lung blood pressuredefinition[GO:0014916]  
1
  • IMPBHF-UCL
  • ISSOrtholog Curator
Retina vasculature development in camera-type eyedefinition[GO:0061298]  
  • ISSOrtholog Curator
Signal transduction by phosphorylationdefinition[GO:0023014]  
  • IEAInterPro 2 GO
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IMPBHF-UCL
Transmembrane receptor protein serine/threonine kinase signaling pathwaydefinition[GO:0007178]  
1
  • IDABHF-UCL
Vascular endothelial growth factor receptor signaling pathwaydefinition[GO:0048010]  
  • ISSOrtholog Curator
Venous blood vessel developmentdefinition[GO:0060841]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.30: ATP + [receptor-protein] ADP + [receptor-protein] phosphate.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium or manganese (By similarity).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cytokine-cytokine receptor interaction  hsa04060+659  
TGF-beta signaling pathway  hsa04350+659  
According to Reactome, this protein belongs to the following pathway:
Signaling by BMP  REACT_12034  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: BMPR2
GenomeRNAi: 659
PRO: PR:Q13873
Chemistry
GuidetoPHARMACOLOGY: 1794