GTF2H3 - General transcription factor IIH subunit 3 - human protein (Function)
 
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GTF2H3 »  General transcription factor IIH subunit 3
 
Protein also known as:  TFIIH basal transcription factor complex p34 subunit.
Gene name:  GTF2H3
Family name: TFB4
Entry whose protein(s) existence is based on evidence at protein level
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1 36 1
GENE REF ISO

Function

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Overview 
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.  
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684]  
1
  • TASPINC
Contributes to DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Contributes to protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
Contributes to RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASPINC
Translation factor activity, nucleic acid bindingdefinition[GO:0008135]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAGOC
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
Translationdefinition[GO:0006412]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+2967  
Nucleotide excision repair  hsa03420+2967  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
DNA Repair  REACT_216  
Gene Expression  REACT_71  
Transcription  REACT_1788  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2967
PRO: PR:Q13889