GTF2H3 - General transcription factor IIH subunit 3 - human protein (Function)
 
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GTF2H3 »  General transcription factor IIH subunit 3
 
Protein also known as:  TFIIH basal transcription factor complex p34 subunit.
Gene name:  GTF2H3
Family name: TFB4
Entry whose protein(s) existence is based on evidence at protein level
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1 37 2
GENE REF ISO

Function

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Overview 
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.  
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684]  
1
  • TASPINC
Contributes to DNA-dependent ATPase activitydefinition[GO:0008094]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Contributes to protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein N-terminus bindingdefinition[GO:0047485]  
1
  • IPIUniProtKB
Contributes to RNA polymerase II carboxy-terminal domain kinase activitydefinition[GO:0008353]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASPINC
Translation factor activity, nucleic acid bindingdefinition[GO:0008135]  
1
  • TASPINC
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
1
  • IDAGOC
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAGOC
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • IDAUniProtKB
Translationdefinition[GO:0006412]  
1
  • TASGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Basal transcription factors  hsa03022+2967  
Nucleotide excision repair  hsa03420+2967  
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  REACT_311  
Dual incision reaction in TC-NER  REACT_2222  
Formation of HIV elongation complex in the absence of HIV Tat  REACT_22201  
Formation of HIV-1 elongation complex containing HIV-1 Tat  REACT_6346  
Formation of incision complex in GG-NER  REACT_257  
Formation of the Early Elongation Complex  REACT_846  
Formation of the HIV-1 Early Elongation Complex  REACT_6319  
Formation of transcription-coupled NER (TC-NER) repair complex  REACT_1941  
HIV Transcription Initiation  REACT_6332  
mRNA Capping  REACT_1470  
NoRC negatively regulates rRNA expression  REACT_200856  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_975  
RNA Pol II CTD phosphorylation and interaction with CE  REACT_6237  
RNA Polymerase I Chain Elongation  REACT_2204  
RNA Polymerase I Promoter Escape  REACT_1913  
RNA Polymerase I Transcription Initiation  REACT_953  
RNA Polymerase I Transcription Termination  REACT_1074  
RNA Polymerase II HIV Promoter Escape  REACT_6253  
RNA Polymerase II Pre-transcription Events  REACT_22107  
RNA Polymerase II Promoter Escape  REACT_2089  
RNA Polymerase II Transcription Elongation  REACT_833  
RNA Polymerase II Transcription Initiation  REACT_1851  
RNA Polymerase II Transcription Initiation And Promoter Clearance  REACT_834  
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening  REACT_1655  
Tat-mediated elongation of the HIV-1 transcript  REACT_6162  
Transcription of the HIV genome  REACT_6233  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2967
PRO: PR:Q13889